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Iris Pinheiro
Researcher at Flanders Institute for Biotechnology
Publications - 24
Citations - 2032
Iris Pinheiro is an academic researcher from Flanders Institute for Biotechnology. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 14, co-authored 21 publications receiving 1549 citations. Previous affiliations of Iris Pinheiro include Ghent University.
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The X chromosome in immune functions: when a chromosome makes the difference
TL;DR: This work reviews the main mechanisms responsible for increased immune activity in females, which provides a survival advantage in the face of pathogenic insult but can also enhance the susceptibility of females to autoimmunity.
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Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?
Lien Dejager,Iris Pinheiro,Iris Pinheiro,Eline Dejonckheere,Eline Dejonckheere,Claude Libert,Claude Libert +6 more
TL;DR: It is demonstrated that experimental sepsis models do not completely mimic human sepsi, and several therapies proposed on the basis of promising results obtained by CLP could not be translated to the clinic.
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X-chromosome-located microRNAs in immunity: might they explain male/female differences?: the X chromosome-genomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females
TL;DR: It is hypothesize that X chromosome‐associated mechanisms, which affect X‐linked genes and are behind the immunological advantage of females, may also affectX‐linked microRNAs, which have important functions in immunity and cancer.
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The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro
Massimo Marzorati,Barbara Vanhoecke,Tine De Ryck,Mehdi Sadaghian Sadabad,Iris Pinheiro,Sam Possemiers,Pieter Van den Abbeele,Lara Derycke,Marc Bracke,Jan Pieters,Tom Hennebel,Hermie J. M. Harmsen,Willy Verstraete,Tom Van de Wiele +13 more
TL;DR: The HMI module offers the possibility of co-culturing a gut representative microbial community with enterocyte-like cells up to 48 h and may therefore contribute to the mechanistic understanding of host-microbiome interactions.
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Arabinogalactan and fructooligosaccharides improve the gut barrier function in distinct areas of the colon in the Simulator of the Human Intestinal Microbial Ecosystem
TL;DR: Results suggest that AG could be an interesting supplement for those conditions characterized by inflammation and increased permeability in the distal colon, and both fibres exerted a potential positive effect on gut barrier and inflammation.