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Isabel Arnold
Researcher at University of Cologne
Publications - 5
Citations - 830
Isabel Arnold is an academic researcher from University of Cologne. The author has contributed to research in topics: Respiratory chain & Translocase of the inner membrane. The author has an hindex of 5, co-authored 5 publications receiving 811 citations. Previous affiliations of Isabel Arnold include Lincoln's Inn.
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c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny
Isabel Arnold,Fiona M. Watt +1 more
TL;DR: It is proposed that transient activation of c-Myc drives keratinocytes from the stem to the transit-amplifying compartment and thereby stimulates proliferation and differentiation along the epidermal and sebaceous lineages.
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Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment.
TL;DR: It is proposed that Myc stimulates exit from the stem cell compartment by reducing adhesive interactions with the local microenvironment or niche, and that the failure of hair differentiation reflects an inability of keratinocytes to migrate along the outer root sheath to receive hair inductive stimuli.
Journal ArticleDOI
Membrane protein degradation by AAA proteases in mitochondria.
Isabel Arnold,Thomas Langer +1 more
TL;DR: This review will summarize the current understanding of this proteolytic system and focus on the mechanisms guiding the degradation of membrane proteins by AAA proteases.
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Characterization of Peptides Released from Mitochondria EVIDENCE FOR CONSTANT PROTEOLYSIS AND PEPTIDE EFFLUX
TL;DR: A constant efflux of peptides from mitochondria is demonstrated and new insight is provided into the stability of the mitochondrial proteome and the efficiency of mitochondrial biogenesis.
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Evidence for a novel mitochondria-to-nucleus signalling pathway in respiring cells lacking i-AAA protease and the ABC-transporter Mdl1.
TL;DR: The findings suggest the existence of a novel mitochondria-to-nucleus signalling pathway in respiring cells which allows the re-adjustment of the biogenesis of the respiratory chain in response to an altered activity of the F1FO-ATP synthase.