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Isabel Beucler
Researcher at Pierre-and-Marie-Curie University
Publications - 3
Citations - 2754
Isabel Beucler is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Coronary artery disease & Low-density lipoprotein receptor gene family. The author has an hindex of 3, co-authored 3 publications receiving 2470 citations.
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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.
Marianne Abifadel,Mathilde Varret,Jean-Pierre Rabès,Delphine Allard,Khadija Ouguerram,Martine Devillers,Corinne Cruaud,Suzanne Benjannet,Louise Wickham,D. Erlich,Aurélie Derré,Ludovic Villéger,Michel Farnier,Isabel Beucler,Eric Bruckert,Jean Chambaz,Bernard Chanu,Jean-Michel Lecerf,Gérald Luc,Philippe Moulin,Jean Weissenbach,Annick Prat,Michel Krempf,Claudine Junien,Nabil G. Seidah,Catherine Boileau +25 more
TL;DR: Two mutations in the gene PCSK9 (encoding proprotein convertase subtilisin/kexin type 9) that cause ADH are reported, a newly identified human subtilase that is highly expressed in the liver and contributes to cholesterol homeostasis.
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Usefulness in predicting coronary artery disease by ultrasonic evaluation of the carotid arteries in asymptomatic hypercholesterolemic patients with positive exercise stress tests
Philippe Giral,Eric Bruckert,Francois Dairou,Kamal Boubrit,Gérard Drobinski,John Chapman,Isabel Beucler,Gérard Turpin +7 more
TL;DR: The combination of clinical, electrical, and echographic data facilitates cost-effective noninvasive detection of CAD in asymptomatic hypercholesterolemic patients and significantly improved the diagnostic specificity of exercise electrocardiography.
Journal ArticleDOI
Features of the Metabolic Syndrome of “Hypertriglyceridemic Waist” and Transplant Coronary Artery Disease
Mario Sénéchal,Isabelle Lemieux,Isabel Beucler,Gérard Drobinski,Sylvie Cormont,Michelle Dubois,Iradj Gandjbakhch,Jean-Pierre Després,Richard Dorent +8 more
TL;DR: The presence of the atherogenic metabolic triad identified patients at high risk of CAD even in the heart transplant population and measurement and interpretation of waist circumference and fasting triglycerides could be used among heart transplant patients to early identify men characterized by the presence of elevated fasting insulin and apolipoprotein B concentrations and small LDL particles.