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Isabel C. Lopez-Mejia
Researcher at University of Lausanne
Publications - 38
Citations - 1723
Isabel C. Lopez-Mejia is an academic researcher from University of Lausanne. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 16, co-authored 31 publications receiving 1176 citations. Previous affiliations of Isabel C. Lopez-Mejia include Centre national de la recherche scientifique & University of Montpellier.
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Journal ArticleDOI
Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism
Aurélien Trompette,Eva S. Gollwitzer,Céline Pattaroni,Isabel C. Lopez-Mejia,Erika Riva,Julie Pernot,Niki D.J. Ubags,Lluis Fajas,Laurent P. Nicod,Benjamin J. Marsland,Benjamin J. Marsland +10 more
TL;DR: A diet rich in the fermentable fiber inulin and the associated metabolites—short‐chain fatty acids—improve the response of mice to influenza infection by dampening deleterious immunopathology caused by neutrophils while enhancing anti‐viral CD8+ T cell responses through a boost in T cell metabolism.
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Splicing-directed therapy in a new mouse model of human accelerated aging.
Fernando G. Osorio,Claire Navarro,Juan Cadiñanos,Isabel C. Lopez-Mejia,Pedro M. Quirós,Catherine Bartoli,José Rivera,Jamal Tazi,Gabriela Guzmán,Ignacio Varela,Danielle Depetris,Félix de Carlos,Juan Cobo,Vicente Andrés,Annachiara De Sandre-Giovannoli,José M.P. Freije,Nicolas Lévy,Carlos López-Otín +17 more
TL;DR: Antisense oligonucleotides reverse premature aging and extend life span in mutant mice that mimic aberrant splicing in progeria patients and develop an antisense morpholino–based therapy that prevents the pathogenic Lmna splicing.
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Mammalian Target of Rapamycin Complex 2 Controls CD8 T Cell Memory Differentiation in a Foxo1-Dependent Manner.
Lianjun Zhang,Benjamin O. Tschumi,Isabel C. Lopez-Mejia,Susanne Oberle,Marten Meyer,Guerric Samson,Markus A. Rüegg,Michael N. Hall,Lluis Fajas,Dietmar Zehn,Jean-Pierre Mach,Alena Donda,Pedro Romero +12 more
TL;DR: It is shown that mTORC2 is a critical regulator of CD8 T cell differentiation and may be an important target for immunotherapy interventions.
Journal ArticleDOI
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis
Pierre-Damien Denechaud,Isabel C. Lopez-Mejia,Albert Giralt,Qiuwen Lai,Emilie Blanchet,Brigitte Delacuisine,Brandon Nicolay,Nicholas J. Dyson,Caroline Bonner,François Pattou,Jean-Sébastien Annicotte,Lluis Fajas +11 more
TL;DR: The data demonstrate that E2F1 regulates lipid synthesis and glycolysis and thus contributes to the development of liver pathology.
Journal ArticleDOI
Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells.
Godehard Scholz,Camilla Jandus,Lianjun Zhang,Camille Grandclément,Isabel C. Lopez-Mejia,Charlotte Soneson,Mauro Delorenzi,Mauro Delorenzi,Lluis Fajas,Werner Held,Olivier Dormond,Pedro Romero +11 more
TL;DR: The data identify a mechanism of pharmacological mTORC1 inhibitors, allowing us to confer stemness to human naive T cells which may be significantly relevant for the design of innovative T cell-based cancer immunotherapies.