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Isabelle Frémaux
Researcher at French Institute of Health and Medical Research
Publications - 15
Citations - 1485
Isabelle Frémaux is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Innate immune system & Chemokine. The author has an hindex of 12, co-authored 12 publications receiving 1357 citations. Previous affiliations of Isabelle Frémaux include Centre national de la recherche scientifique & University of Angers.
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The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps
Sébastien Jaillon,Giuseppe Peri,Yves Delneste,Isabelle Frémaux,Andrea Doni,Federica Moalli,Cecilia Garlanda,Luigina Romani,Hugues Gascan,Silvia Bellocchio,Silvia Bozza,Marco A. Cassatella,Pascale Jeannin,Alberto Mantovani +13 more
TL;DR: The long pentraxin (PTX) 3 is produced by macrophages and myeloid dendritic cells in response to Toll-like receptor agonists and represents a nonredundant component of humoral innate immunity against selected pathogens.
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Direct Stimulation of Human T Cells via TLR5 and TLR7/8: Flagellin and R-848 Up-Regulate Proliferation and IFN-γ Production by Memory CD4 + T Cells
Gersende Caron,Dorothée Duluc,Isabelle Frémaux,Pascale Jeannin,Catherine David,Hugues Gascan,Yves Delneste +6 more
TL;DR: Data demonstrate for the first time a direct effect of TLR5 and TLR7/8 ligands on human T cells, and highlight an innate arm in T cell functions, and suggest that some components from invading microorganisms may directly stimulate effector memory T cells located in tissues by up-regulating cytokine and chemokine production.
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Histamine and prostaglandin E2 up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-γ-induced CXCL10 production by immature human dendritic cells
Anne Mcilroy,Gersende Caron,Simon Blanchard,Isabelle Frémaux,Dorothée Duluc,Yves Delneste,Alain Chevailler,Pascale Jeannin +7 more
TL;DR: Results show that, in addition to polarizing DC into mature cells that promote naïve T‐cell differentiation into Th2 cells, histamine and PGE2 may act on immature DC to trigger local Th2 cell recruitment through a selective control of Th1/Th2‐attracting chemokine production, thereby contributing to maintain a microenvironment favourable to persistent immunoglobulin E synthesis.
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IL‐34 and macrophage colony‐stimulating factor are overexpressed in hepatitis C virus fibrosis and induce profibrotic macrophages that promote collagen synthesis by hepatic stellate cells
Laurence Preisser,Charline Miot,Hélène Le Guillou-Guillemette,Elodie Beaumont,Etienne D. Foucher,Erwan Garo,Simon Blanchard,Isabelle Frémaux,Anne Croue,Isabelle Fouchard,Françoise Lunel-Fabiani,Jérôme Boursier,Philippe Roingeard,Paul Calès,Yves Delneste,Pascale Jeannin +15 more
TL;DR: It is reported that chronically HCV‐infected patients with high fibrosis stages have higher serum levels of macrophage colony‐stimulating factor (M‐CSF) and interleukin (IL)−34 than HCVs with lower fibrosis levels and healthy subjects.
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Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.
Pierre Cunin,Céline Beauvillain,Charline Miot,Jean-François Augusto,Laurence Preisser,Simon Blanchard,Pascale Pignon,Mari Scotet,Erwan Garo,Isabelle Frémaux,Alain Chevailler,Jean-François Subra,Patrick Blanco,Mark R. Wilson,Pascale Jeannin,Yves Delneste +15 more
TL;DR: Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains, and is identified as a new molecule partner involved in apoptotic cell efferocytosis.