I
Isabelle Seif
Researcher at University of Paris-Sud
Publications - 67
Citations - 5701
Isabelle Seif is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: Serotonin & Monoamine oxidase A. The author has an hindex of 33, co-authored 67 publications receiving 5532 citations. Previous affiliations of Isabelle Seif include Curie Institute & Université Paris-Saclay.
Papers
More filters
Journal ArticleDOI
Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA
Olivier Cases,Isabelle Seif,Joseph Grimsby,Patricia Gaspar,Kevin Chen,Sandrine Pournin,Ulrike Müller,Michel Aguet,Charles Babinet,Jean C. Shih,Edward De Maeyer +10 more
TL;DR: Pup behavioral alterations, including trembling, difficulty in righting, and fearfulness were reversed by the serotonin synthesis inhibitor parachlorophenylalanine, and adults manifested a distinct behavioral syndrome, including enhanced aggression in males.
Journal ArticleDOI
Lack of Barrels in the Somatosensory Cortex of Monoamine Oxidase A-Deficient Mice: Role of a Serotonin Excess during the Critical Period
Olivier Cases,Tania Vitalis,Isabelle Seif,Edward De Maeyer,Constantino Sotelo,Patricia Gaspar +5 more
TL;DR: It is shown that the primary somatosensory cortex (S1) lacks the characteristic barrel-like clustering of layer IV neurons, whereas normal pattern formation exists in the thalamus and the trigeminal nuclei.
Journal ArticleDOI
Transient Uptake and Storage of Serotonin in Developing Thalamic Neurons
Cécile Lebrand,Olivier Cases,Christine Adelbrecht,Anne Doye,Chantal Alvarez,Salah El Mestikawy,Isabelle Seif,Patricia Gaspar +7 more
TL;DR: It is shown that the dense transient 5-HT innervation of the somatosensory, visual, and auditory cortices originates in the thalamus rather than in the raphe, which means internalized 5- HT might be stored and used as a "borrowed transmitter" for extraneuronal signaling or could exert an intraneuronal control on thalamic maturation.
Journal ArticleDOI
Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice.
Nathalie Salichon,Patricia Gaspar,A. Louise Upton,Sandrine Picaud,Naïma Hanoun,Michel Hamon,Edward De Maeyer,Dennis L. Murphy,Rainald Mössner,Klaus-Peter Lesch,René Hen,Isabelle Seif +11 more
TL;DR: Because the 5-HT1B receptor inhibits glutamate release, the results suggest that visual and somatosensory projections must release glutamate for proper segregation and suggests that serotonergic drugs represent a risk for the development of these projections.
Journal ArticleDOI
Type I IFN as a Natural Adjuvant for a Protective Immune Response: Lessons from the Influenza Vaccine Model
Enrico Proietti,Laura Bracci,Simona Puzelli,Tiziana Di Pucchio,Paola Sestili,Enrico De Vincenzi,Massimo Venditti,Imerio Capone,Isabelle Seif,Edward De Maeyer,David F. Tough,Isabella Donatelli,Filippo Belardelli +12 more
TL;DR: It is demonstrated that endogenous type I IFN is necessary for the Th1 type of immune response induced by typical adjuvants in mice and that IFN itself is an unexpectedly powerful adjuvant when administered with the human influenza vaccine.