F
Filippo Belardelli
Researcher at Istituto Superiore di Sanità
Publications - 288
Citations - 19007
Filippo Belardelli is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Immune system & Interferon. The author has an hindex of 66, co-authored 287 publications receiving 17758 citations. Previous affiliations of Filippo Belardelli include Sapienza University of Rome & National Institutes of Health.
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Journal ArticleDOI
Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo.
Agnes Le Bon,Giovanna Schiavoni,Giuseppina D'Agostino,Ion Gresser,Filippo Belardelli,David F. Tough +5 more
TL;DR: The data show that IFN-I potently enhance the primary antibody response to a soluble protein, stimulating the production of all subclasses of IgG, and induce long-lived antibody production and immunological memory.
Journal ArticleDOI
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Antonella Sistigu,Takahiro Yamazaki,Erika Vacchelli,Kariman Chaba,David Enot,Julien Adam,Ilio Vitale,Aicha Goubar,Elisa E. Baracco,Catarina Remédios,Laetitia Fend,Dalil Hannani,Laetitia Aymeric,Yuting Ma,Mireia Niso-Santano,Oliver Kepp,Joachim L. Schultze,Thomas Tüting,Filippo Belardelli,Laura Bracci,Valentina La Sorsa,Giovanna Ziccheddu,Paola Sestili,Francesca Urbani,Mauro Delorenzi,Magali Lacroix-Triki,Virginie Quidville,Rosa Conforti,Jean Philippe Spano,Lajos Pusztai,Vichnou Poirier-Colame,Suzette Delaloge,Frédérique Penault-Llorca,Sylvain Ladoire,Laurent Arnould,Joanna Cyrta,Marie Charlotte Dessoliers,Alexander M.M. Eggermont,Marco Bianchi,Mikael J. Pittet,Camilla Engblom,Christina Pfirschke,Xavier Préville,Gilles Uzé,Robert D. Schreiber,Melvyn T. Chow,Mark J. Smyth,Enrico Proietti,Fabrice Andre,Guido Kroemer,Laurence Zitvogel +50 more
TL;DR: The data suggest that anthracycline-mediated immune responses mimic those induced by viral pathogens, and it is surmised that such 'viral mimicry' constitutes a hallmark of successful chemotherapy.
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Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl-Scid Mice
Stefano M. Santini,Caterina Lapenta,Mariantonia Logozzi,Stefania Parlato,Massimo Spada,Tiziana Di Pucchio,Filippo Belardelli +6 more
TL;DR: The results provide a rationale for using type I IFNs as vaccine adjuvants and support the concept that a natural alliance between these cytokines and monocytes/DCs represents an important early mechanism for connecting innate and adaptive immunity.
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Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer
TL;DR: An extensive overview of the multiple immune-based mechanisms exploited by the most commonly employed cytotoxic drugs is provided, with the final aim of identifying prerequisites for optimal combination with immunotherapy strategies for the development of more effective treatments against cancer.
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Type I interferons produced by dendritic cells promote their phenotypic and functional activation.
Maria Montoya,Giovanna Schiavoni,Fabrizio Mattei,Ion Gresser,Filippo Belardelli,Persephone Borrow,David F. Tough +6 more
TL;DR: It is shown that murine DCs undergo phenotypic maturation upon exposure to type I interferons (type I IFNs) in vivo or in vitro, identifying type Iinterferons as autocrine DC activators.