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Isamu Hoshino
Researcher at Chiba University
Publications - 121
Citations - 2573
Isamu Hoshino is an academic researcher from Chiba University. The author has contributed to research in topics: Cancer & Esophageal cancer. The author has an hindex of 24, co-authored 110 publications receiving 2182 citations. Previous affiliations of Isamu Hoshino include Michigan State University.
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Casein kinase 1 is recruited to nuclear speckles by FAM83H and SON.
Takahisa Kuga,Hideaki Kume,Jun Adachi,Naoko Kawasaki,Maiko Shimizu,Isamu Hoshino,Hisahiro Matsubara,Youhei Saito,Yuji Nakayama,Takeshi Tomonaga +9 more
TL;DR: It is suggested that CK1 is recruited to nuclear speckles by FAM83H and SON in the absence of an intact keratin cytoskeleton in colorectal cancer tissues.
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Primary esophageal adenocarcinoma arising from heterotopic gastric mucosa: report of a case
Naoki Akanuma,Isamu Hoshino,Yasunori Akutsu,Kiyohiko Shuto,Toru Shiratori,Tsuguaki Kono,Masaya Uesato,Asami Sato,Yuka Isozaki,Tetsuro Maruyama,Nobuyoshi Takeshita,Hisahiro Matsubara +11 more
TL;DR: The patient has remained alive for more than 4 years after surgery, without any evidence of recurrence, and the tumor was identified to be a well-differentiated adenocarcinoma arising from HGM with invasion to the muscularis propria.
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Tip30 Deletion in MMTV-Neu Mice Leads to Enhanced EGFR Signaling and Development of Estrogen Receptor–Positive and Progesterone Receptor–Negative Mammary Tumors
Chengliang Zhang,Mikito Mori,Shenglan Gao,Aimin Li,Isamu Hoshino,Mark D. Aupperlee,Sandra Z. Haslam,Hua Xiao +7 more
TL;DR: It is shown thatTip30 deletion dramatically accelerated the onset of mammary tumors in the MMTV-Neu mouse model of breast cancer, and it is found that Tip30 regulates the EGFR pathway through controlling endocytic downregulation of EGFR protein level and signaling.
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Antitumor effects of metformin are a result of inhibiting nuclear factor kappa B nuclear translocation in esophageal squamous cell carcinoma.
Nobufumi Sekino,Masayuki Kano,Yasunori Matsumoto,Haruhito Sakata,Yasunori Akutsu,Naoyuki Hanari,Kentaro Murakami,Takeshi Toyozumi,Masahiko Takahashi,Ryota Otsuka,Masaya Yokoyama,Tadashi Shiraishi,Koichiro Okada,Isamu Hoshino,Keiko Iida,Aki Komatsu Akimoto,Hisahiro Matsubara +16 more
TL;DR: Analysis of the antitumor effects of metformin clarified its effects on anti‐inflammation, growth suppression and EMT inhibition and found that localization of NF‐κB in the nucleus was reduced after met formin treatment.
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Histone Demethylase LSD1 Inhibitors Prevent Cell Growth by Regulating Gene Expression in Esophageal Squamous Cell Carcinoma Cells
Isamu Hoshino,Yasunori Akutsu,Kentaro Murakami,Naoki Akanuma,Yuka Isozaki,Tetsuro Maruyama,Takeshi Toyozumi,Yasunori Matsumoto,Hiroshi Suito,Masahiko Takahashi,Nobufumi Sekino,Aki Komatsu,Takayoshi Suzuki,Hisahiro Matsubara +13 more
TL;DR: Observations of the comprehensive analysis of the gene expression levels provide insight into the mechanisms underlying the antitumor effects of LSD1 inhibitors in ESCC patients.