S
Sandra Z. Haslam
Researcher at Michigan State University
Publications - 85
Citations - 4687
Sandra Z. Haslam is an academic researcher from Michigan State University. The author has contributed to research in topics: Mammary gland & Estrogen. The author has an hindex of 41, co-authored 84 publications receiving 4346 citations.
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Journal Article
Estrogenic Effects of Genistein on the Growth of Estrogen Receptor-positive Human Breast Cancer (MCF-7) Cells in Vitro and in Vivo
TL;DR: Dietary genistein can act as an estrogen agonist in vivo and in vitro, resulting in the proliferation of cultured human breast cancer cells (MCF-7) and the induction of pS2 gene expression.
Journal ArticleDOI
Hormone replacement therapy with estrogen or estrogen plus medroxyprogesterone acetate is associated with increased epithelial proliferation in the normal postmenopausal breast.
TL;DR: It is shown that postmenopausal HRT with E+P was associated with greater breast epithelial cell proliferation and breast epithelium density than E alone or no HRT, and breast proliferation was localized to the terminal duct-lobular unit of the breast, which is the site of development of most breast cancers.
IARC monographs programme on the evaluation of carcinogenic risks to humans
Garnet L. Anderson,Philippe Autier,Valerie Beral,Maarten C. Bosland,Esteve Fernández,Sandra Z. Haslam,David G. Kaufman,Carlo La Vecchia,Alfredo A. Molinolo,Polly A. Newcomb,Fritz F. Parl,Julian Peto,Giuseppe Rosano,Deodutta Roy,Frank Z. Stanczyk,David B. Thomas,Lars J. Vatten,Ted Junghans,Steve Olin,Samuel Shapiro,Randall S. Stafford,C. W. Jameson,Jens U. Meyer,Robert Baan,Julien Berthiller,Vincent Cogliano,Carolyn M. Dresler,Fatiha El Ghissassi,Silvia Franceschi,Maria Alice G. Gonçalves,Yann Grosse,Neela Guha,Manuela Marron,Jane Mitchell,Nikolai Napalkov,Béatrice Secretan,Kurt Straif,Andreas Ullrich,Sandrine Egraz,Brigitte Kajo,Martine Lézère,Helene Lorenzen-Augros +41 more
TL;DR: The programme to evaluate the carcinogenic risk of chemicals to humans and to produce monographs on individua1 chemica1s has since been expanded to include consideration of exposures to comp1ex mixtures of chemica 1s and of Exposure to other agents, such as radiation and viruses.
Journal ArticleDOI
Mammary gland growth and development from the postnatal period to postmenopause: ovarian steroid receptor ontogeny and regulation in the mouse.
TL;DR: Current understanding of estrogen and progesterone receptordistribution in epithelial and stromal cells and their functions in relation to mammary gland development is presented.
Journal ArticleDOI
Radiation acts on the microenvironment to affect breast carcinogenesis by distinct mechanisms that decrease cancer latency and affect tumor type.
David H. Nguyen,David H. Nguyen,Hellen A. Oketch-Rabah,Irineu Illa-Bochaca,Felipe C. Geyer,Jorge S. Reis-Filho,Jian-Hua Mao,Shraddha A. Ravani,Jiri Zavadil,Alexander D. Borowsky,D. Joseph Jerry,Karen A. Dunphy,Jae Hong Seo,Sandra Z. Haslam,Daniel Medina,Mary Helen Barcellos-Hoff +15 more
TL;DR: The irradiated microenvironment affects latency and clinically relevant features of cancer through distinct and unexpected mechanisms, including TGFβ mediated tumor acceleration.