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Isei Tanida
Researcher at Juntendo University
Publications - 97
Citations - 32916
Isei Tanida is an academic researcher from Juntendo University. The author has contributed to research in topics: Autophagy & GABARAP. The author has an hindex of 47, co-authored 92 publications receiving 28782 citations. Previous affiliations of Isei Tanida include National Institutes of Health & University of Tokyo.
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Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy
Tomokazu Mizui,Shunhei Yamashina,Isei Tanida,Yoshiyuki Takei,Takashi Ueno,Naoya Sakamoto,Kenichi Ikejima,Tsuneo Kitamura,Nobuyuki Enomoto,Tatsuo Sakai,Eiki Kominami,Sumio Watanabe +11 more
TL;DR: The results of this study suggest that the replication of HCV replicon utilizes machinery involving cellular autophagic proteolysis, which may provide a new therapeutic option against chronic hepatitis C.
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Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression.
Yoshihiro Inami,Shunhei Yamashina,Kousuke Izumi,Takashi Ueno,Isei Tanida,Kenichi Ikejima,Sumio Watanabe +6 more
TL;DR: It is demonstrated that hepatic steatosis impairs autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression in hepatocytes from ob/ob mice.
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GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.
TL;DR: The results indicate that GATE-16 and GABARAP are authentic modifiers, but that they have different biochemical characteristics from those of LC3.
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Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains.
Takahide Kouno,Mineyuki Mizuguchi,Isei Tanida,Takashi Ueno,Takashi Kanematsu,Yoshihiro Mori,Hiroyuki Shinoda,Masato Hirata,Eiki Kominami,Keiichi Kawano +9 more
TL;DR: It is shown that two subdomains of the LC3-I structure have distinct functions, suggesting that MAP-LC3 can act as an adaptor protein between microtubules and autophagosomes.
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Cooperation of Calcineurin and Vacuolar H+-ATPase in Intracellular Ca2+Homeostasis of Yeast Cells
TL;DR: The results suggest that calcineurin controls calcium homeostasis by repression of Ca2+flux into a cellular compartment(s) and that the vacuolar H+-ATPase is essential for cell growth cooperating with calcineURin to regulate the cytosolic free concentration of Ca1+ in the vma3 mutant cells.