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Ishana Harkoo
Researcher at Centre for the AIDS Programme of Research in South Africa
Publications - 15
Citations - 155
Ishana Harkoo is an academic researcher from Centre for the AIDS Programme of Research in South Africa. The author has contributed to research in topics: Medicine & Dapivirine. The author has an hindex of 3, co-authored 9 publications receiving 38 citations. Previous affiliations of Ishana Harkoo include University of KwaZulu-Natal.
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Safety, uptake, and use of a dapivirine vaginal ring for HIV-1 prevention in African women (HOPE): An open-label, extension study
Jared M. Baeten,Thesla Palanee-Phillips,Nyaradzo Mgodi,Ashley J Mayo,Daniel W. Szydlo,Gita Ramjee,Brenda Gati Mirembe,Felix Mhlanga,Portia Hunidzarira,Leila E. Mansoor,Samantha Siva,Vaneshree Govender,Bonus Makanani,Logashvari Naidoo,Nishanta Singh,Gonasagrie Nair,Lameck Chinula,Urvi M. Parikh,John W. Mellors,Iván C. Balán,Kenneth Ngure,Ariane van der Straten,Ariane van der Straten,Rachel Scheckter,Morgan Garcia,Melissa Peda,Karen Patterson,Edward Livant,Katherine E. Bunge,Devika Singh,Cindy Jacobson,Yuqing Jiao,Craig W. Hendrix,Zvavahera M Chirenje,Clemensia Nakabiito,Taha E. Taha,Judith G. Jones,Kristine Torjesen,Annalene Nel,Zeda F. Rosenberg,Lydia Soto-Torres,Sharon L. Hillier,Elizabeth R. Brown,Elizabeth R. Brown,Dorothy Aanyu,John Abima,Janne Abullarade,Priyanka Agarwal,Surabhi Ahluwalia,Simon Africa Akasiima,Carolyne Akello,Samuel Albert,Motsamai Alphale,Calins Alphonse,Lucy Apeduno,Sara Aranda,Orly Aridor,Shakeera Arnolds,Prossy Asiimwe,Millicent Atujuna,Didas Atwebembere,Lakshmi Baboolall,Kiran Badana,David Balamusani,Gabriel Banda,Towera Whitney Banda,Jennifer Baugh,James Amos Baziira,M.A. Beamer,Sivuyisiwe Asanda Bebeza,Linda-Gail Bekker,Ian Bell,Meagan Bemer,Richard Berman,Jennifer Berthiaume,Linda Bezak,Yashveer Bhagwandin,Hassen Anwar Bhayat,Nokulunga Bhengu,Sonto Bhengu,Aruna Bhoola,Florence Asiimwe Biira,Daniel Bittoni,Roberta Black,Nombuso Jacqueline Blose,Pearl Boks,Stephen Gordon Bolton,Phathiswa Botya,Amanda Brown,Elizabeth Brown,Helen Brown,Robyn Helen Bruce,Luke Erismus Bukenya,Aidah Bukirwa,Lisa Bunts,Fezile Buthelezi,Mbongeleni William Buthelezi,Samkelisiwe Dumisile Buthelezi,Rose Byogero,Samiksha Byroo,Robert Byuma,Johanna Albertha Carstens,Allison Carter,Nazneen Cassim,Busisiwe Cebekhulu,Bongekile Cele,Dolly Judith Cele,Phindile Cele,Simangele Cele,Sithabile Cele,Mary Chadza,Nahida Chakhtoura,Claire Chapdu,Gift Tafadzwa Chareka,Charles Chasakara,Manju Chatani-Gada,Diana Chetty,Mary Chidanyika,Tafadzwa Tariro Lisa Chifambi,Emelder Chihota,Sungano Chikono,Anesu Chikonyora,Brett Dzidzai Chikukwa,Craig Chin,Mary Chindevu,Tendai Blessing Chinyanda,Thandiwe Hilda Chirenda,Zvavahera M. Chirenje,Chiedza Chirisa,Patience Chisale,Angela Chishanga,Tobias Chitambo,Fred Chitema,Flora Chithila,Tinei Helen Chitowa,Catherine Chitsinde,Gladys Chitsulo,Miria Chitukuta,Spiwe Chiveso,Nelecy Chome,Phumelele Fortune Chonco,Emily Christopher,Kerusha Chunderduri,Vutomi Cibi,Naana Cleland,Thobeka Coba,Mandy Rae Cobbing,Clare Collins,Kim Comer,Shameen Cozzi,Danielle Crida,Sufia Dadabhai,Thembakazi Daki,Nwabisa Danster,Reshmi Dassaye,Renita David,Jontraye M. Davis,Sumaya Dawood,Pallabi Deb,Leslie Degnam,Tiffany Sharron Derrick,Brid Devlin,Charlene S. Dezzutti,Patricia Mae Dhlakama,Lorna Dias,Jean Chivoniso Dimairo,Elaine Dinnie,Avile Dlabanta,Msizi Dladla,Thandeka Immaculate Dladla,Andile Princess Dlungele,Curtis Dolezal,Kristine Donaty,Clare Dott,Jenna Dubbs,Vuyiseka Dubula-Majola,Pamella Dukwe,Cebo Ivan Duma,Portia Ignatia Makhosazana Duma,Promise Duma,Vimbai Kudzanai Duncan,Luis Duran,Lindelwa Dyabeni,Andrew Edwards,Radhika Etikala,Juliane Etima,Lee Fairlie,Henry Fischer,Jacqueline Fitzpatrick,Llewellyn Fleurs,Mary Glenn Fowler,Lester Freeman,Zakir Gaffoor,Lizzy Gama,Anita Garg,Vanesa Margret Gatsi,Clifford Gcwensa,Emmanuel Lwandile Gebashe,Samantha Geduld,Jennipher Gelant,Donna Germuga,Joseph Ggita,Rebecca Giguere,Lucy Godo,B. Jay Goetz,Litha Gogo,Esther Goliati,Daniel Kondwani Gondwe,Kelley C. Gordon,Rodney Goreraza,Jayandree Gounden,Dhevium Govender,Justin Sivalingum Govender,Nerusha Govender,Subramonien Govender,Nonkululeko Nosipho Gqwara,Anisa (Tracy) Gravelle,Phindile Guga,Victor Guma,Delisile Zilungile Gumede,Sibusiso Gumede,Thembelihle Gumede,Thobeka Winifred Gumede,Orgrah Gundani,Ravi Gunnam,Rashmi Gupta,Mirriam Gwande,Xolani Gxako,Kim Hall,Wayne Hall,Perry Hargrave,Ishana Harkoo,Tanya M. Harrell,Amy L. Heaps,Simone Lara Hendricks,Bongeka Hlabisa,Lungile Bongeka Hlabisa,Kudzai Hlahla,Thulebona Martin Hlela,Thandiwe Hobongwana,Eva Horn,Ridley Howard,Haixiao Huang,Portia Hunidzairia,Nivriti Hurbans,Marla Husnik,Tendai Doreen Hwehwe,Rabia Imamdin,Amina Ismail,Ebrahiema Jacobs,Ashleigh Catherine Jacques,Jane Jamabya,Grace James,Karla Janse van Rensburg,Ziningi Nobuhle Jaya,Nitesha Jeenarain,Lauren Jennings,Haoping Jiang,Ning Jiang,Nwabisa Laurianne Jijana,Godfrey Jokoniya,Mildred Kabasonga,Daniel Kizza Kabenge,Samuel Kabwigu,Evans Kachale,Lonely Kachenjera,Fiona Kachingamire,Emma Kachipapa,Mary Kadiwa,McLoddy Kadyamusuma,Bosco Kafufu,Mary Mukasa Kagwa,Clare Kajura-Manyindo,Brenda Catherine Kakayi,Victoria Kaliwo,Dishiki Jenny Kalonji,Nyasha Elizabeth Kamanga,Betty Kamira,Zerif Kampangire,Getrude Kamwana,Justine Kamya,La-Donna Kapa,Patrick Karugaba,Khumbo Kasambara,Priya Kassim,Sheetal Kassim,Milly Katana,Francis Katongole,Sulaiman Katongole,Alexis Katsis,Chaplain Katumbi,Ariana W K Katz,Edmore Kawanje,Caroline Nassozi Kawuma,Sowedi Kayongo,Emily Kekana,Doreen Kemigisha,Siphosihle Khanyile,Nombuso Happiness Khanyisile,Babalwa Khaya,Noluthando Khiya,Norah Ntombikayise Khoza,Thembisile Khumalo,Christina Khwela,Zamo Khwela,Edith Kibiribiri,Ismael Kibirige,Beatrice Kiiza,Florence Sempa Kikonyogo,Melissa Kin,Catherine Kirkwood,Girisha Kistnasami,Flavia Matovu Kiweewa,Max Kiweewa,Deepika Konatham,Lungile Kubheka,Terrence Kufakunesu,Phaleda Kumwenda,Wiza Wisdom Isaac Kumwenda,Maura Kush,Bryan A. Kutner,Ntomboxolo Kwatsha,Rosper Kwedza,Erinah Kyomukama,Debra Lands,Phumelele Nokuthula Langa,Kalkidan Lebeta,Cody Lentz,Brendley Tebogo Leremi,Michelle Leszczewski,Lisa Levy,Ted Livant,Irene Lukas,Lungile Pearl Mabanga,Nomusa Mabaso,Vimbainashe Machisa,Toni M. Maddox,Bernadette Madlala,Nocwaka Magobiane,Melda Magolela,Fungai Maguramhinga,Phumzile Desiree Magwaza,Keshnee Maharaj,Ferial Mahed,Tankiso Vuyiswa Mahlase,Moshukutjoane Lebogang Maila,Yvonne Makala,Patrick Makamure,Kgabo Phineas Makgoka,Pamela Makhamba,Nompumelelo Makhanya,Rulani Makondo,Rujeko Makoni,Henry Makooka,Jennie Makunganya,Sibongile Makwenda,Gakiema Malan,Agnes Malemia,Mariëtte Malherbe,Faith Malunga,Temantfulini Mamba Nhassengo,Mogau Mampa,Tendai Karen Mamvura,Elmah Manengamambo,Loreen Zandile Mangove,Nomvuyo Mangxilana,Tsungai Patience Manjera,Winifred Elizabeth Mans,Leila Mansoor,Memory Maoko,Annie Mapfunde,Nonhlanhla Yvonne Maphumulo,Francis Martinson,Abel Maruwo,Emmerentia Yvonne Marx,Mark A. Marzinke,Moira Masango,Mmathabo Nnana Mashego,Gwendoline Thotele Refilwe Mashinini,Shingirayi Irene Masuko,Kudzai Viviana Matambanadzo,Florence Mathebula,Matheus Mathipa,Jacob Munyaradzi Matsa,Eleanor Agnes Matta,Allen Taguma Matubu,Ayanda Comfort Mavundla,Sandile Mavundla,Billy Mawindo,Josiah Mayani,Emmanuel Mayanja,Nombongo Mayekiso,Nonkululeko Precious Mayisela,Mary Speciosa Mbabali,Nonhlakanipho Masibonge Gciniwe Mbanjwa,Constance Seanokeng Mbatha,Nomcedo Janice Mbatha,Dorica Mbewe,Tinkhani Mbichila,Yamikani Mbilizi,Sithokoza Mbokazi,Mwandifitsa Mbwerera,Zethu Mchunu,Laura McKinstry,Bongiwe Mdlongwa,Sihle Perfect Meyiwa,Nyaradzo Mavis Mgodi,Erasmus Samuel Mhizha,Nomsa Sibongile Mhlanga,Brenda Gail Mirembe,Dorothy Mirembe,Fumbani Mkandawire,Ntombizethu Hazel Mkhabela,Baningi Mkhize,Princess Hlengiwe Mkhize,Zaba Mkhize,Elizabeth Gugu Mlangeni,Margaret Mlingo,Bukiwe Mngqebisa,Noluxolo Mngxekeza,Anele Mninzi,Nonzwakazi Mnqonywa,Mammekwa Mogkoro,Thembisile Wilmah Mogodiri,Rebone Frengelina Mohuba,Maseponki Cecilia Mokoena,Noxolo Mona,Deidra Montoya,Willie Monyethabeng,Jayajothi Moodley,Jeeva Moodley,Kerushini Moodley,Suri Moonsamy,Neetha S. Morar,Sophie Nomsa Morudu,Angela Mpekula,Gerald Thsepo Mphisa,Jayne Mpofu,Hlengiwe Theodora Mposula,Avril Mqadi,Emmie Msiska,Lusungu Msumba,Nana Mtambo,Emmanuel Sinothi Mthalane,Thabisile Susan Mthembu,Zanoxolo Mthethi,Magdeline Judith Mthethwa,Ntokozo Zabathethwa Mthethwa,Sicelo Samuel Mthimkhulu,Itsepheng Mtlokoa,Michael Charles Mubiru,Mary Mudavanhu,Anna Zvirevo Mufumisi,Agnes Mary Mugagga,Joanita Muganga,Michelle Mugava,Margaret Mugenyi,Caroline Mugocha,Faith Mugodhi,Norma Mugwagwa,Felix Godwin Sivhukile Muhlanga,Shorai Mukaka,Dick Mukasa,Restituta Mukasa,Mathews Mukatipa,Shedina Mukova,Sarah Mulebeke,Joyce Mulima,Julio Muller,Faith Mulumba,Tsitsi Mupamombe,Constance Murandu,Tarisai Murefu,Fungai Murewa,Kudakwashe Muringayi,Caroline Murombedzi,Petina Musara,Jane Nsubuga Musisi,Mary Maria Musisi,Philippa Musoke,Joseph Mutebo,Prisca Mutero,Kudzai Santana Mutiti,Shadreck Mutizira,Sharon Mutsvunguma,Netsai Muungani,Tariro Muvunzi,Rosemary Muwawu,Samkelisiwe Mvelase,Priscilla Pamela Mvinjelwa,Goodness Zoh Mvuyane,Liness Mwafulirwa,Pokiwe Mwagomba,Thoko Gift Mwakhwawa,Deborah Mwebaza,Wezi Mwenda,Nqobile Myeni,Angeline Doreen Nonhlanhla Mzolo,Regina Bukenya Nabatanzi,Joselyne Nabisere,Josephine Nabukeera,Christine Valerie Nagawa,Cherise Naicker,Kumari Naicker,Vimla Naicker,Ishana Naidoo,Jason Naidoo,Jayganthie Naidoo,Kalendri Naidoo,Renissa Naidoo,Sandy Naidoo,Nalini Naidu,Gonasagrie Lulu Nair,Susan Nakacwa,Joyce Gladys Nakakande,Rita Nakalega,Maria Gorreti Nakalema,Jesca Nakibuka,Teopista Nakyanzi,Justine Nakyeyune,Stella Nalusiba,Rhoda Namakula,Felix Namalueso,Paula Mubiru Namayanja,Christine Tapuwa Nampala,Suzan Nkalubo Nampiira,Agnes Namuddu,Norah Nandundu,Winnie Nansamba,Stella Nanyonga,Sophie Clare Nanziri,Zainab Nakivumbi Nassoma,Duduzile Ethel Ncube,Eva Ncube,Sithabile Ncube,Pepukayi Ndadziyira,Pamella Pumla Ndamase,Walter Seth Taurayi Nderecha,Zanele Ndhlovu-Forde,Thembelihle Cynthia Ndimande,Bukekile Ndlovu,Grecenia Ndlovu,James Ndlovu,Nontokozo Happiness Ndlovu,Thakisile Nontokozo Ndlovu,Zodwa Ndlovu,Margret Ndovie,Beauty Nemasango,Blazej Neradilek,Susan Ngani,Nokwanda Queeneth Ngcebethsha,Lizbon Ngcobela,Nolwazi Ngcobo,Nompumelelo Ngcobo,Sindisiwe Promise Ngcobo,Nidleka Ngcukana,Julie Ngo,Nontshukumo Ngqabe,Siyabonga Ngqame,Mduduzi Dawood Ngubane,Nancy Nokuthula Ngwenya,Mugowe Nhkoma,Bongiwe Ntombizodwa Nhlapho,Sibusiso Nhleko,Hlengiwe Nkwanyana,Heather Noble,Lumka Lucia Nobula,Monica Nolan,Mluleki Nompondwana,Busiwe Notshokovu,Vukani Sandile Ntanzi,Nishi Nursaye,Jeremy Peter Nutall,Omega Nyabadza,Evelesi Nyaka,Sandra Nyakudya,Envioletta Chiedza Nyakura,Shingayi Nyamadzawo,Tsitsi Nyamuzihwa,Zubayiri Nyanzi,Angel Tinny Nyathi,Fadire Nyirenda,Makandwe Nyirenda,Mary Nyirenda,Sinqobile Charity Nzama,Lamec Sbongisomi Nzuza,Bhavesha O'Byrne,Fabian Okello,Eunice Okumu,Emmanuel Oluka,Francis Onen,Carolyne Peris Onyango,Katherine Ostbye,Kerusha Padayachee,Victor Palichina,Zhenyu Pan,Colin Pappajohn,Levanya Paramanund,Nazmie Pearce,Kerri J. Penrose,Bathandekile Molly Phahlamohlaka,Nokulunga Ruth Phidane,Omisha Pillay,Anamika Premrajh,Nikita Prosad,Lorna K. Rabe,Alishka Rajman,Keneoe Maphuti Rampai,Hlalifi Sylvia Rampyapedi,April Randhawa,Sabelo Rasmeni,Dianne Rausch,Avanita Reddy,Isayum Reddy,Jerusha Reddy,Krishnaveni Reddy,Vera Helen Rees,Andrea Repetto,Cheryl Richards,Sharon A. Riddler,Nobubele Rini,Brendon Roeber,Lisa C. Rohan,Zachary Romer,Matthew Rose,Zeda Fran Rosenberg,Lisa Rossi,Aviva Ruch,Christine Rullo,Sinazo Runeyi,Olivia Rupemba,Chenai Rushwaya,Marisa Russell,Patience Sharai Ruzive,Godfrey Rwanzogyera,Margaret Nakato Saava,Tshepo Jimmy Sagela,Rebecca Sakwa,Fathima Sayed,Jennifer Schille,Nokwayintombi Scotch,William Scott,Caitlin Scoville,Richard Sebagala,Elaine Sebastian,Natasha Tina Sedze,Nasreen Hoosen Seedat,Joseph Semakula,Teri Senn,Francis Serugo,Linly Seyama,Bhekanani Khumulani Shabalala,Charlotte Phumzile Shangase,Pamela Caroline Shanhinga,Jeremy Shaver,Hanjie Shen,Mogobalale Corlett Shogole,Rachel Shonhiwa,Claudia Shozi,Marvelous Sibanda,Sylvia Sibongile Sibeko,Ncamisile Teressa Sibisi,Samuel Siphelele Sibisi,Brighty Zweni Sibiya,Happiness Sibiya,Dorothy Sichali,Phumzile Yvonne Sikosana,Craig Silva,Ayanda Purity Simelane,Melissa Simon,Triesha Sing,Hailey Virginia Sithole,Edith Sitima,Alex Siyasiya,Vuyane Sizane,Bekezela Siziba,Edward Slezinger,Daria Smolinski,Katie Snapinn,Olwethu Sogoni,Dean Soko,Leonard Nichiren Solai,Mandiphumle Somga,Mei Song,Xiaoling Song,Devarani Soobryan,Lydia Soto-Torres,Patrick Spence,Elizabeth Spooner,Vincent Sseguya,Augustine Ssentongo,Mark Ssenyonga,Lawrence Lollian Sseremba,Michael Stais,John Steytler,Sharon Stockton,Julie Stofel,Tinyiko Reginah Stuurman,Sizakele Sukazi,Jasmin Lynn Sukdao,Kranthi Swarna,Daniel Szydlo,Christine Tagliaferri Rael,Dorothy Rumbidzai Taguta,Taha Taha,Eunice Tahuringana,Joshua Tamale,Penelope Tambama,Edna Taulo,Frank Taulo,Thelma Tonderai Tauya,Gerald Tegha,Sindisiwe Lucia Tembe,Tchangani Tembo,Constance Lebo Thatelo,Pinky Mery Thobela,Annie Thom,Christine Thompson,Monica Thompson,Linda Thusi,Lauri Tock,Thandokazi Tofile,Carol Tranfaglia,Jenny Tseng,Themba Tshabalala,Nomvuselelo Tshongoyi,Mercy Tsidya,Wendy Rufaro Tsikiwa,NoCamagu Tuswa-Haynes,Bomkazi Onini Tutshana,Andile Premrose Twala,Ashvir Viren Udith,Christine Unten,Neliëtte van Niekerk,Amanda Varela,Nangamso Vatsha,Gayathri Vijayendran,Amukelani California Vuma,Deo Wabwire,Madalo Walani,Bhekisisa Wanda,Lisa Wasberg,Rhonda White,Kathleen Marie Windle,Kubashni Woeber,Danica Wright,Tiffanee Wright,Thembalethu Nontokozo Xaba,Makanaka Jean Savie Yambira,Ntando Yola,Sindisiwe Lydia Zaca,Aisha Zalwango,Jullian Zemanek,Chifundo Zimba,Tsitsi Zinyengere,Margaret Zinyongo,Thabile Goodness Zondi,Chun Zou,Jabulisile Zuma,Nokuthula Princess Zungu,Nompumelelo Zungu +760 more
TL;DR: In this article, the use of a monthly vaginal ring containing 25 mg dapivirine was well tolerated and reduced HIV-1 incidence in women by approximately 30% compared with placebo.
Journal ArticleDOI
Pregnancy and infant outcomes among women using the dapivirine vaginal ring in early pregnancy
Bonus Makanani,Jennifer E. Balkus,Yuqing Jiao,Lisa M. Noguchi,Thesla Palanee-Phillips,Yamikani Mbilizi,Jothi Moodley,Kenneth Kintu,Krishnaveni Reddy,Samuel Kabwigu,Nitesha Jeenariain,Ishana Harkoo,Nyaradzo Mgodi,Jeanna M. Piper,Helen Rees,Rachel Scheckter,Richard H. Beigi,Jared M. Baeten +17 more
TL;DR: Dapivirine use in the periconception period does not seem to be associated with adverse effects on pregnancy or infant outcomes, and these findings provide support for additional safety studies of the dapvirine ring throughout pregnancy.
Journal ArticleDOI
CAPRISA 018: a phase I/II clinical trial study protocol to assess the safety, acceptability, tolerability and pharmacokinetics of a sustained-release tenofovir alafenamide subdermal implant for HIV prevention in women
Tanuja N. Gengiah,Quarraisha Abdool Karim,Ishana Harkoo,Leila E. Mansoor,Nonhlanhla Yende Zuma,Precious Radebe,Natasha Samsunder,Cheryl Baxter,Bhavna. Maharaj,Marc M. Baum,John A. Moss,Bruno Pozzetto,Catherine Hankins,Salim S. Abdool Karim +13 more
TL;DR: A phase I/II trial to evaluate the safety, acceptability, tolerability and pharmacokinetics (PKs) of a TAF free base subdermal silicone implant containing 110’mg of TAF with an anticipated 0.25 mg/day release rate in healthy women at low risk for HIV infection.
Journal ArticleDOI
Acceptability of the Dapivirine Vaginal Ring for HIV-1 Prevention and Association with Adherence in a Phase III Trial.
Ashley J Mayo,Erica N Browne,Elizabeth T. Montgomery,Kristine Torjesen,Thesla Palanee-Phillips,Nitesha Jeenarain,Linly Seyama,Kubashni Woeber,Ishana Harkoo,Krishnaveni Reddy,Tchangani Tembo,Prisca Mutero,Thelma Tonderai Tauya,Miria Chitukuta,Brenda Gati Mirembe,Lydia Soto-Torres,Elizabeth R. Brown,Jared M. Baeten,Ariane van der Straten,Ariane van der Straten,Mtn,Aspire Study Team +21 more
TL;DR: In this article, the acceptability of the 25mg dapivirine vaginal ring (DVR) as an HIV prevention intervention and its influence on DVR adherence in the MTN-020/ASPIRE phase III trial was evaluated.
Journal ArticleDOI
Brief Report: Anal Intercourse, HIV-1 Risk, and Efficacy in a Trial of a Dapivirine Vaginal Ring for HIV-1 Prevention.
Kathryn Peebles,van der Straten A,Thesla Palanee-Phillips,K Reddy,Sharon L. Hillier,Craig W. Hendrix,Ishana Harkoo,Gati Mirembe B,Nitesha Jeenarain,Jared M. Baeten,Elizabeth R. Brown +10 more
TL;DR: RAI was modestly infrequent and was not associated with reduced HIV-1 protection from the ring, suggesting that, in populations with rates of RAI similar to this cohort, RAI may not appreciably reduce the population-level impact of the dapivirine vaginal ring.