I
Israel Salguero
Researcher at University of Cambridge
Publications - 17
Citations - 1584
Israel Salguero is an academic researcher from University of Cambridge. The author has contributed to research in topics: DNA repair & DNA replication. The author has an hindex of 9, co-authored 16 publications receiving 1338 citations. Previous affiliations of Israel Salguero include University of Oxford & University of Extremadura.
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Journal ArticleDOI
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
Claire Palles,Jean-Baptiste Cazier,Kimberley Howarth,Enric Domingo,Angela M. Jones,Peter Broderick,Zoe Kemp,Sarah L. Spain,Estrella Guarino,Israel Salguero,Amy L. Sherborne,Daniel Chubb,Luis G. Carvajal-Carmona,Yusanne Ma,Kulvinder Kaur,Sara E. Dobbins,Ella Barclay,Maggie Gorman,Lynn Martin,Michal Kovac,Michal Kovac,Sean Humphray,Anneke Lucassen,Christopher Holmes,David Bentley,Peter Donnelly,Peter Donnelly,Jenny C. Taylor,Christos Petridis,Rebecca Roylance,Elinor J. Sawyer,David J. Kerr,Susan K. Clark,Jonathan M. Grimes,Stephen E. Kearsey,Huw Thomas,Gilean McVean,Richard S. Houlston,Ian Tomlinson +38 more
TL;DR: A recently described group of hypermutant, microsatellite-stable CRCs is likely to be caused by somatic POLE mutations affecting the exonuclease domain, predicted to cause a defect in the correction of mispaired bases inserted during DNA replication.
Journal ArticleDOI
Erratum: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas (Nature Genetics (2013) 45 (136-144))
Claire Palles,Jean-Baptiste Cazier,Kimberley Howarth,Enric Domingo,Alison Jones,Peter Broderick,Zoe Kemp,Sarah L. Spain,E G Almeida,Israel Salguero,Amy L. Sherborne,Daniel Chubb,Luis G. Carvajal-Carmona,Yussanne Ma,Kulvinder Kaur,S Dobbins,Ella Barclay,Margaret Gorman,Lynn Martin,Michal Kovac,Sean Humphray,Anneke Lucassen,Christopher Holmes,David Bentley,Peter Donnelly,Jenny C. Taylor,Christos Petridis,Rebecca Roylance,Elinor J. Sawyer,David J. Kerr,Susan K. Clark,Jonathan M. Grimes,Stephen E. Kearsey,Thomas Hjw.,Gil McVean,Richard S. Houlston,I. P. M. Tomlinson +36 more
TL;DR: The aim of this work is to contribute to the understanding of why certain types of mutations occur in people over a long period of time and to contribute towards the design of treatments for these diseases.
Journal ArticleDOI
Genome architecture and stability in the Saccharomyces cerevisiae knockout collection
Fabio Puddu,Fabio Puddu,Mareike Herzog,Mareike Herzog,Alexandra Selivanova,Siyue Wang,Jin Zhu,Shir Klein-Lavi,Molly Gordon,Roi Meirman,Gonzalo Millán-Zambrano,Iñigo Ayestaran,Israel Salguero,Roded Sharan,Rong Li,Martin Kupiec,Stephen P. Jackson +16 more
TL;DR: Whole-genome sequencing of the strains of the Saccharomyces cerevisiae gene-knockout collection reveals the effects of the deletion of non-essential genes on genome stability and describes the genomic alterations that are induced by its loss.
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Cellular regulation of ribonucleotide reductase in eukaryotes.
TL;DR: Additional mechanisms of control responsible for providing a balanced supply of dNTPs, including regulation of expression of RNR genes, proteolysis of R NR subunits, control of the cellular localization of the small RNR subunit, and regulation of Rnr activity by small protein inhibitors are focused on.
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Double-Strand Break Generation under Deoxyribonucleotide Starvation in Escherichia coli
TL;DR: Stalled replication forks produced by three different ways of depleting deoxynucleoside triphosphate showed different capacities to undergo "replication fork reversal," which occurred at the stalled forks generated by hydroxyurea treatment.