M
Maggie Gorman
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 26
Citations - 4920
Maggie Gorman is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Genome-wide association study & Endometrial cancer. The author has an hindex of 20, co-authored 26 publications receiving 4550 citations. Previous affiliations of Maggie Gorman include Cancer Research UK.
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Journal ArticleDOI
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
Ian Tomlinson,Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Zoe Kemp,Sarah L. Spain,Steven Penegar,Ian Chandler,Maggie Gorman,Wendy Wood,Ella Barclay,Steven J. Lubbe,Lynn Martin,Gabrielle S. Sellick,Emma Jaeger,Richard A. Hubner,Ruth Wild,Andrew Rowan,Sarah Fielding,Kimberley Howarth,Andrew Silver,Wendy Atkin,Kenneth Muir,Richard F A Logan,David J. Kerr,Elaine C. Johnstone,Oliver M. Sieber,Richard Gray,Huw Thomas,Julian Peto,Jean-Baptiste Cazier,Richard S. Houlston +32 more
TL;DR: These data show that common, low-penetrance susceptibility alleles predispose to colorectal neoplasia, and suggest that susceptibility to CRC is mediated through development of adenomas.
Journal ArticleDOI
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
Claire Palles,Jean-Baptiste Cazier,Kimberley Howarth,Enric Domingo,Angela M. Jones,Peter Broderick,Zoe Kemp,Sarah L. Spain,Estrella Guarino,Israel Salguero,Amy L. Sherborne,Daniel Chubb,Luis G. Carvajal-Carmona,Yusanne Ma,Kulvinder Kaur,Sara E. Dobbins,Ella Barclay,Maggie Gorman,Lynn Martin,Michal Kovac,Michal Kovac,Sean Humphray,Anneke Lucassen,Christopher Holmes,David Bentley,Peter Donnelly,Peter Donnelly,Jenny C. Taylor,Christos Petridis,Rebecca Roylance,Elinor J. Sawyer,David J. Kerr,Susan K. Clark,Jonathan M. Grimes,Stephen E. Kearsey,Huw Thomas,Gilean McVean,Richard S. Houlston,Ian Tomlinson +38 more
TL;DR: A recently described group of hypermutant, microsatellite-stable CRCs is likely to be caused by somatic POLE mutations affecting the exonuclease domain, predicted to cause a defect in the correction of mispaired bases inserted during DNA replication.
Journal ArticleDOI
A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Ian Tomlinson,Emily L. Webb,Luis G. Carvajal-Carmona,Peter Broderick,Kimberley Howarth,Alan M. Pittman,Sarah L. Spain,Steven J. Lubbe,Axel Walther,Kate Sullivan,Emma Jaeger,Sarah Fielding,Andrew Rowan,Jayaram Vijayakrishnan,Enric Domingo,Ian Chandler,Zoe Kemp,Mobshra Qureshi,Susan M. Farrington,Albert Tenesa,James G. D. Prendergast,Rebecca A. Barnetson,Steven Penegar,Ella Barclay,Wendy Wood,Lynn Martin,Lynn Martin,Lynn Martin,Maggie Gorman,Huw Thomas,Julian Peto,D. Timothy Bishop,Richard Gray,Eamonn R. Maher,Anneke Lucassen,David J. Kerr,D. Gareth Evans,Clemens Schafmayer,Stephan Buch,Henry Völzke,Jochen Hampe,Stefan Schreiber,Ulrich John,Thibaud Koessler,Paul D.P. Pharoah,Tom van Wezel,Hans Morreau,Juul T. Wijnen,John L. Hopper,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Sergi Castellví-Bel,Clara Ruiz-Ponte,Angel Carracedo,Antoni Castells,Asta Försti,Asta Försti,Kari Hemminki,Kari Hemminki,Pavel Vodicka,Alessio Naccarati,Lara Lipton,Judy W. C. Ho,King Yip Cheng,Pak C. Sham,John M. Luk,José A. G. Agúndez,José M. Ladero,Miguel de la Hoya,Trinidad Caldés,Iina Niittymäki,Sari Tuupanen,Auli Karhu,Lauri A. Aaltonen,Jean-Baptiste Cazier,Harry Campbell,Malcolm G. Dunlop,Richard S. Houlston +79 more
TL;DR: Genetic data provide further evidence for the 'common-disease common-variant' model of CRC predisposition and identify two previously unreported associations.
Journal ArticleDOI
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Peter Broderick,Luis G. Carvajal-Carmona,Luis G. Carvajal-Carmona,Alan M. Pittman,Emily L. Webb,Kimberley Howarth,Andrew Rowan,Steven J. Lubbe,Sarah L. Spain,Kate Sullivan,Sarah Fielding,Emma Jaeger,Jayaram Vijayakrishnan,Zoe Kemp,Maggie Gorman,Ian Chandler,Elli Papaemmanuil,Steven Penegar,Wendy Wood,Gabrielle S. Sellick,Mobshra Qureshi,Ana Teixeira,Enric Domingo,Ella Barclay,Lynn Martin,Lynn Martin,Oliver M. Sieber,David J. Kerr,Richard Gray,Julian Peto,Jean-Baptiste Cazier,Ian Tomlinson,Ian Tomlinson,Richard S. Houlston +33 more
TL;DR: Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (Ptrend = 1.0 × 10−12), and three SNPs in SMAD7 (involved in TGF-β and Wnt signaling) associated with CRC were identified.
Journal ArticleDOI
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Richard S. Houlston,Jeremy Peter Cheadle,Sara E. Dobbins,Albert Tenesa,Angela M. Jones,Kimberley Howarth,Sarah L. Spain,Peter Broderick,Enric Domingo,Susan M. Farrington,James G. D. Prendergast,Alan M. Pittman,Evi Theodoratou,Christopher Smith,Bianca Olver,Axel Walther,Rebecca A. Barnetson,Michael Churchman,Emma Jaeger,Steven Penegar,Ella Barclay,Lynn Martin,Maggie Gorman,Rachel Mager,Elaine C. Johnstone,Rachel Midgley,Iina Niittymäki,Sari Tuupanen,James Colley,Shelley Idziaszczyk,Huw Thomas,Anneke Lucassen,D. Gareth Evans,Eamonn R. Maher,Tim Maughan,Antigone S. Dimas,Antigone S. Dimas,Emmanouil T. Dermitzakis,Jean-Baptiste Cazier,Lauri A. Aaltonen,Paul D.P. Pharoah,David J. Kerr,David J. Kerr,Luis G. Carvajal-Carmona,Harry Campbell,Malcolm G. Dunlop,Ian Tomlinson +46 more
TL;DR: A meta-analysis of three GWAS from the UK provides evidence that additional CRC-associated variants of similar effect size remain to be discovered and identifies four new CRC risk loci.