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Angela M. Jones
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 27
Citations - 3563
Angela M. Jones is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 20, co-authored 27 publications receiving 3199 citations. Previous affiliations of Angela M. Jones include London Research Institute & University of Oxford.
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Journal ArticleDOI
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
Claire Palles,Jean-Baptiste Cazier,Kimberley Howarth,Enric Domingo,Angela M. Jones,Peter Broderick,Zoe Kemp,Sarah L. Spain,Estrella Guarino,Israel Salguero,Amy L. Sherborne,Daniel Chubb,Luis G. Carvajal-Carmona,Yusanne Ma,Kulvinder Kaur,Sara E. Dobbins,Ella Barclay,Maggie Gorman,Lynn Martin,Michal Kovac,Michal Kovac,Sean Humphray,Anneke Lucassen,Christopher Holmes,David Bentley,Peter Donnelly,Peter Donnelly,Jenny C. Taylor,Christos Petridis,Rebecca Roylance,Elinor J. Sawyer,David J. Kerr,Susan K. Clark,Jonathan M. Grimes,Stephen E. Kearsey,Huw Thomas,Gilean McVean,Richard S. Houlston,Ian Tomlinson +38 more
TL;DR: A recently described group of hypermutant, microsatellite-stable CRCs is likely to be caused by somatic POLE mutations affecting the exonuclease domain, predicted to cause a defect in the correction of mispaired bases inserted during DNA replication.
Journal ArticleDOI
Associations of Breast Cancer Risk Factors With Tumor Subtypes: A Pooled Analysis From the Breast Cancer Association Consortium Studies
Xiaohong R. Yang,Jenny Chang-Claude,Ellen L. Goode,Fergus J. Couch,Heli Nevanlinna,Roger L. Milne,Mia M. Gaudet,Marjanka K. Schmidt,Annegien Broeks,Angela Cox,Peter A. Fasching,Rebecca Hein,Amanda B. Spurdle,Fiona M. Blows,Kristy Driver,Dieter Flesch-Janys,J Heinz,Peter Sinn,Alina Vrieling,Tuomas Heikkinen,Kristiina Aittomäki,Päivi Heikkilä,Carl Blomqvist,Jolanta Lissowska,Beata Peplonska,S. Chanock,Jonine D. Figueroa,Louise A. Brinton,Per Hall,Kamila Czene,Keith Humphreys,Hatef Darabi,Jianjun Liu,Laura J. Van 'T Veer,Flora E. van Leeuwen,Irene L. Andrulis,Gord Glendon,Julia A. Knight,Anna Marie Mulligan,Frances P O'Malley,Nayana Weerasooriya,Esther M. John,Matthias W. Beckmann,Arndt Hartmann,Sebastian B. Weihbrecht,David L. Wachter,Sebastian M. Jud,Christian R. Loehberg,Laura Baglietto,Dallas R. English,Graham G. Giles,Catriona McLean,Gianluca Severi,Diether Lambrechts,T. Vandorpe,Caroline Weltens,Robert Paridaens,Ann Smeets,Patrick Neven,Hans Wildiers,Xianshu Wang,Janet E. Olson,Victoria Cafourek,Zachary S. Fredericksen,Matthew L. Kosel,Celine M. Vachon,Helen Cramp,Daniel Connley,Simon S. Cross,Sabapathy P. Balasubramanian,Malcolm W.R. Reed,Thilo Dörk,Michael Bremer,Andreas Meyer,Johann H. Karstens,Aysun Ay,Tjoung Won Park-Simon,Peter Hillemanns,Jose Ignacio Arias Perez,Primitiva Menéndez Rodríguez,P. Zamora,Javier Benítez,Yon Ko,Hans Fischer,U Hamann,Beate Pesch,Thomas Brüning,Christina Justenhoven,Hiltrud Brauch,Diana Eccles,William J. Tapper,Sue Gerty,Elinor J. Sawyer,Ian Tomlinson,Angela M. Jones,Michael J. Kerin,Nicola Miller,Niall M. McInerney,Hoda Anton-Culver,Argyrios Ziogas,Chen-Yang Shen,Chia-Ni Hsiung,Pei Ei Wu,Show Lin Yang,Jyh Cherng Yu,Shou Tung Chen,Giu Cheng Hsu,Christopher A. Haiman,Brian E. Henderson,Loic Le Marchand,Laurence N. Kolonel,Annika Lindblom,Sara Margolin,Anna Jakubowska,Jan Lubinski,Tomasz Huzarski,Tomasz Byrski,Bohdan Górski,Jacek Gronwald,Maartje J. Hooning,Antoinette Hollestelle,Ans M.W. van den Ouweland,Agnes Jager,Mieke Kriege,Madeleine M.A. Tilanus-Linthorst,Margriet Collée,Shan Wang-Gohrke,Katri Pylkäs,Arja Jukkola-Vuorinen,Kari Mononen,Mervi Grip,Pasi Hirvikoski,Robert Winqvist,Arto Mannermaa,Veli-Matti Kosma,Jaana M. Kauppinen,Vesa Kataja,Päivi Auvinen,Ylermi Soini,Reijo Sironen,Stig E. Bojesen,David Dynnes Ørsted,Diljit Kaur-Knudsen,Henrik Flyger,Børge G. Nordestgaard,Helene Holland,Georgia Chenevix-Trench,Siranoush Manoukian,M. Barile,Paolo Radice,Susan E. Hankinson,David J. Hunter,Rulla M. Tamimi,Suleeporn Sangrajrang,Paul Brennan,James McKay,Fabrice Odefrey,Valerie Gaborieau,Peter Devilee,P. E.A. Huijts,Raem Tollenaar,Caroline Seynaeve,Gillian S. Dite,Carmel Apicella,John L. Hopper,Fleur Hammet,Helen Tsimiklis,Letitia D. Smith,Melissa C. Southey,Manjeet K. Humphreys,Douglas F. Easton,Paul D.P. Pharoah,Mark E. Sherman,Montserrat Garcia-Closas +173 more
TL;DR: It is shown that reproductive factors and BMI are most clearly associated with hormone receptor-positive tumors and suggest that triple-negative or CBP tumors may have distinct etiology.
Journal ArticleDOI
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33
Richard S. Houlston,Jeremy Peter Cheadle,Sara E. Dobbins,Albert Tenesa,Angela M. Jones,Kimberley Howarth,Sarah L. Spain,Peter Broderick,Enric Domingo,Susan M. Farrington,James G. D. Prendergast,Alan M. Pittman,Evi Theodoratou,Christopher Smith,Bianca Olver,Axel Walther,Rebecca A. Barnetson,Michael Churchman,Emma Jaeger,Steven Penegar,Ella Barclay,Lynn Martin,Maggie Gorman,Rachel Mager,Elaine C. Johnstone,Rachel Midgley,Iina Niittymäki,Sari Tuupanen,James Colley,Shelley Idziaszczyk,Huw Thomas,Anneke Lucassen,D. Gareth Evans,Eamonn R. Maher,Tim Maughan,Antigone S. Dimas,Antigone S. Dimas,Emmanouil T. Dermitzakis,Jean-Baptiste Cazier,Lauri A. Aaltonen,Paul D.P. Pharoah,David J. Kerr,David J. Kerr,Luis G. Carvajal-Carmona,Harry Campbell,Malcolm G. Dunlop,Ian Tomlinson +46 more
TL;DR: A meta-analysis of three GWAS from the UK provides evidence that additional CRC-associated variants of similar effect size remain to be discovered and identifies four new CRC risk loci.
Journal ArticleDOI
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk
Malcolm G. Dunlop,Sara E. Dobbins,Susan M. Farrington,Angela M. Jones,Claire Palles,Nicola Whiffin,Albert Tenesa,Sarah L. Spain,Peter Broderick,Li-Yin Ooi,Enric Domingo,Claire Smillie,Marc Henrion,Matthew Frampton,Lynn Martin,Graeme R. Grimes,Maggie Gorman,Colin A. Semple,Yusanne P Ma,Ella Barclay,James G. D. Prendergast,Jean-Baptiste Cazier,Bianca Olver,Steven Penegar,Steven J. Lubbe,Ian Chander,Luis G. Carvajal-Carmona,Stephane Ballereau,Amy Lloyd,Jayaram Vijayakrishnan,Lina Zgaga,Lina Zgaga,Igor Rudan,Evropi Theodoratou,John M. Starr,Ian J. Deary,Iva Kirac,Dujo Kovačević,Lauri A. Aaltonen,Laura Renkonen-Sinisalo,Jukka-Pekka Mecklin,Koichi Matsuda,Yusuke Nakamura,Yukinori Okada,Steven Gallinger,David Duggan,David V. Conti,Polly A. Newcomb,John L. Hopper,Mark A. Jenkins,Fredrick R. Schumacher,Graham Casey,Douglas F. Easton,Mitul Shah,Paul D.P. Pharoah,Annika Lindblom,Tao Liu,Christopher Smith,Hannah West,Jeremy Peter Cheadle,Rachel Midgley,David J. Kerr,Harry Campbell,Harry Campbell,Ian Tomlinson,Ian Tomlinson,Richard S. Houlston +66 more
TL;DR: A meta-analysis of five genome-wide association studies to identify common variants influencing colorectal cancer risk identified three new CRC risk loci at 6p21, 11q13.4 and Xp22, providing further insight into the genetic architecture of inherited susceptibility to CRC.
Journal ArticleDOI
Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer
Ian Tomlinson,Luis G. Carvajal-Carmona,Sara E. Dobbins,Albert Tenesa,Angela M. Jones,Kimberley Howarth,Claire Palles,Peter Broderick,Emma Jaeger,Susan M. Farrington,Annabelle Lewis,James G. D. Prendergast,Alan M. Pittman,Evropi Theodoratou,Bianca Olver,Marion F Walker,Steven Penegar,Ella Barclay,Nicola Whiffin,Lynn Martin,Stephane Ballereau,Amy Lloyd,Maggie Gorman,Steven J. Lubbe,Bryan Howie,Jonathan Marchini,Clara Ruiz-Ponte,Ceres Fernandez-Rozadilla,Antoni Castells,Angel Carracedo,Sergi Castellví-Bel,David Duggan,David V. Conti,Jean-Baptiste Cazier,Harry Campbell,Oliver M. Sieber,Lara Lipton,Peter Gibbs,Nicholas G. Martin,Grant W. Montgomery,Joanne P. Young,Paul N. Baird,Steven Gallinger,Polly A. Newcomb,John L. Hopper,Mark A. Jenkins,Lauri A. Aaltonen,David J. Kerr,Jeremy Peter Cheadle,Paul D.P. Pharoah,Graham Casey,Richard S. Houlston,Malcolm G. Dunlop +52 more
TL;DR: This data emphasise that genetic fine-mapping studies can deconvolute associations that have arisen owing to independent correlation of a tagSNP with more than one functional SNP, thus explaining some of the apparently missing heritability of common diseases.