Itaru Hamachi

TL;DR: A novel semi-wet peptide/protein microarray using a supramolecular hydrogel composed of glycosylated amino acetate that overcomes several drawbacks of conventional protein chips, and thus can have potential applications in pharmaceutical research and diagnosis.

TL;DR: TheTRPC3-selective inhibitor Pyr3 is a powerful tool to study in vivo function of TRPC3, suggesting a pharmaceutical potential of Pyr3 in treatments of TR PC3-related diseases such as cardiac hypertrophy.

TL;DR: The design of fluorescent chemosensors bearing two zinc ions coordinated to distinct dipicolylamine (Dpa) sites is described and it is demonstrated that the binuclear receptors can be useful for the convenient fluorescent detection of a natural phosphatase (PTP1B) catalyzed dephosphorylation.

TL;DR: It is shown that redox-responsive peptide-based hydrogels have the ability to encapsulate enzymes and still retain their activities and Boolean logic gates were built into the hydrogel-enzyme hybrid materials, which were able to sense simultaneously plural specific biochemicals and execute a controlled drug release in accordance with the logic operation.

TL;DR: The first fluorescent chemosensors toward a native phosphorylation peptide are successfully synthesized and it is demonstrated that these artificial receptors fluorometrically detect a phosphorylated peptide with high affinity in aqueous solution.