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Shigeki Kiyonaka
Researcher at Kyoto University
Publications - 108
Citations - 6316
Shigeki Kiyonaka is an academic researcher from Kyoto University. The author has contributed to research in topics: Transient receptor potential channel & Receptor. The author has an hindex of 39, co-authored 101 publications receiving 5616 citations. Previous affiliations of Shigeki Kiyonaka include Laboratory of Molecular Biology & Nagoya University.
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Semi-wet peptide/protein array using supramolecular hydrogel
TL;DR: A novel semi-wet peptide/protein microarray using a supramolecular hydrogel composed of glycosylated amino acetate that overcomes several drawbacks of conventional protein chips, and thus can have potential applications in pharmaceutical research and diagnosis.
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TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration
Shinichiro Yamamoto,Shunichi Shimizu,Shigeki Kiyonaka,Nobuaki Takahashi,Teruaki Wajima,Yuji Hara,Takaharu Negoro,Toshihito Hiroi,Yuji Kiuchi,Takaharu Okada,Shuji Kaneko,Ingo Lange,Andrea Fleig,Reinhold Penner,Miyuki Nishi,Hiroshi Takeshima,Yasuo Mori +16 more
TL;DR: It is shown that the plasma membrane Ca2+-permeable channel TRPM2 controls ROS-induced chemokine production in monocytes, which aggravates inflammation and is proposed as a new therapeutic strategy for treating inflammatory diseases.
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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
Shigeki Kiyonaka,Kenta Kato,Motohiro Nishida,Kazuhiro Mio,Takuro Numaga,Yuichi Sawaguchi,Takashi Yoshida,Minoru Wakamori,Emiko Mori,Tomohiro Numata,Masakazu Ishii,Hiroki Takemoto,Akio Ojida,Kenta Watanabe,Aya Uemura,Hitoshi Kurose,Takashi Morii,Tsutomu Kobayashi,Yoji Sato,Chikara Sato,Itaru Hamachi,Yasuo Mori +21 more
TL;DR: TheTRPC3-selective inhibitor Pyr3 is a powerful tool to study in vivo function of TRPC3, suggesting a pharmaceutical potential of Pyr3 in treatments of TR PC3-related diseases such as cardiac hypertrophy.
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First Thermally Responsive Supramolecular Polymer Based on Glycosylated Amino Acid
TL;DR: This paper clearly demonstrates that, regardless of the low molecular weight, a glycosylated amino acid derivative newly screened by a combinatorial method forms a macroscopic supramolecular hydrogel that reversibly swells or shrinks in response to the external temperature.
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Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia.
Hong-Shuo Sun,Michael F. Jackson,Michael F. Jackson,Loren J. Martin,Karen Jansen,Lucy Teves,Hong Cui,Shigeki Kiyonaka,Yasuo Mori,Michael Jones,Joan P. Forder,Todd E. Golde,Beverley A. Orser,Beverley A. Orser,John F. MacDonald,John F. MacDonald,Michael Tymianski +16 more
TL;DR: Regional suppression of TRPM7 is feasible, well tolerated and inhibits delayed neuronal death in vivo and prevented ischemia-induced deficits in LTP and preserved performance in fear-associated and spatial-navigational memory tasks.