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Iva D. Tzvetanova
Researcher at Max Planck Society
Publications - 14
Citations - 1784
Iva D. Tzvetanova is an academic researcher from Max Planck Society. The author has contributed to research in topics: Oligodendrocyte & Myelin. The author has an hindex of 9, co-authored 12 publications receiving 1464 citations. Previous affiliations of Iva D. Tzvetanova include European University Cyprus & Stony Brook University.
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Journal ArticleDOI
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Ursula Fünfschilling,Lotti Marianna Supplie,Don J. Mahad,Don J. Mahad,Susann Boretius,Aiman S. Saab,Julia M. Edgar,Bastian G. Brinkmann,Celia M. Kassmann,Iva D. Tzvetanova,Wiebke Möbius,Francisca Diaz,Dies Meijer,Ueli Suter,Bernd Hamprecht,Michael W. Sereda,Carlos T. Moraes,Jens Frahm,Sandra Goebbels,Klaus-Armin Nave +19 more
TL;DR: By in vivo magnetic resonance spectroscopy, brain lactate concentrations in mutants were increased compared with controls, but were detectable only in mice exposed to volatile anaesthetics, which indicates that aerobic glycolysis products derived from oligodendrocytes are rapidly metabolized within white matter tracts.
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The role of myelin and oligodendrocytes in axonal energy metabolism.
TL;DR: Studying axo-glial signalling and energy metabolism will lead to a better understanding of neurodegenerative diseases, in which axonal energy metabolism fails, including neurological disorders as diverse as multiple sclerosis, leukodystrophies, and amyotrophic lateral sclerosis.
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Glia unglued: how signals from the extracellular matrix regulate the development of myelinating glia.
TL;DR: The concept of extracellular matrix proteins as environmental sensors that act to integrate, or match, cellular responses, in particular to those downstream of growth factors, to appropriate matrix attachment is emphasized.
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Evaluation of matrix metalloproteinase 7 in plasma and pancreatic juice as a biomarker for pancreatic cancer.
Koert F.D. Kuhlmann,J. W. Olivier van Till,Marja A. Boermeester,Philip R. de Reuver,Iva D. Tzvetanova,G. Johan A. Offerhaus,Fiebo J.W. ten Kate,Olivier R. Busch,Thomas M. van Gulik,Dirk J. Gouma,Howard C. Crawford +10 more
TL;DR: The diagnostic accuracy of matrix metalloproteinase 7 alone is not sufficient to determine treatment strategy in patients with a periampullary mass, but combined evaluation of plasma MMP-7 with CA19-9 and other markers may be clinically useful.
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Laminin Alters Fyn Regulatory Mechanisms and Promotes Oligodendrocyte Development
TL;DR: It is suggested that a normal role for CNS laminin is to promote the development of oligodendrocyte progenitors into myelin-forming oligodendedrocytes via modulation of Fyn regulatory molecules.