Julia M. Edgar

TL;DR: By in vivo magnetic resonance spectroscopy, brain lactate concentrations in mutants were increased compared with controls, but were detectable only in mice exposed to volatile anaesthetics, which indicates that aerobic glycolysis products derived from oligodendrocytes are rapidly metabolized within white matter tracts.

TL;DR: It is suggested that many AONDs can be categorized as dysferopathies, diseases in which alterations in AT represent a critical component in pathogenesis, and Illumination of such mechanisms provides a framework for the development of novel therapeutic strategies aimed to prevent axonal and synaptic dysfunction in several major Aonds.

TL;DR: The integrative approach of live imaging, electron microscopy, and genetics are used to show that new myelin membranes are incorporated adjacent to the axon at the innermost tongue, ultimately leading to the formation of a set of closely apposed paranodal loops.

TL;DR: A novel role for oligodendrocytes in the local regulation of axonal function is demonstrated and implications for the axonal loss associated with secondary progressive multiple sclerosis are implications.

TL;DR: Advances in advances in both areas are reviewed, focusing on the molecular mechanisms underlying axonal loss in acute inflammation and in chronic demyelination, and discussing how the restoration of myelin sheaths via the regenerative process of remyelinated might prevent axon degeneration.