Ivy Hsieh

TL;DR: This study provides proof of concept that cysteine protease inhibitors can be given at therapeutic doses to animals to selectively arrest a parasitic infection.

TL;DR: A new role is identified for UBQLN in regulating the maturation of autophagy, expanding the involvement of ubiquitin‐related proteins in this process.

TL;DR: Defining the role of each of these major enzymes provides a clearer understanding of the function of a complex protease network that is conserved throughout invertebrate evolution and provides insights into which of these proteases are logical targets for development of chemotherapy for schistosomiasis, a major global health problem.

TL;DR: It is reported that specific cysteine protease inhibitors kill Leishmania parasites in vitro, at concentrations that do not overtly affect mammalian host cells.

TL;DR: It is shown that deletion of the central fission protein dynamin-related protein 1 (Drp1) is critical for targeting mitochondria to the nerve terminal, and a disruption in mitochondrial fission can contribute to the preferential death of nigrostriatal DA neurons.