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Iwan A. T. Schaap
Researcher at University of Göttingen
Publications - 52
Citations - 3996
Iwan A. T. Schaap is an academic researcher from University of Göttingen. The author has contributed to research in topics: Virus & Indentation. The author has an hindex of 27, co-authored 51 publications receiving 3510 citations. Previous affiliations of Iwan A. T. Schaap include University of Glasgow & National Institute for Medical Research.
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Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication.
Russell P. Goodman,Iwan A. T. Schaap,Iwan A. T. Schaap,C. F. Tardin,C. F. Tardin,Christoph M. Erben,Christoph M. Erben,Richard M. Berry,Richard M. Berry,Christoph F. Schmidt,Christoph F. Schmidt,Andrew J. Turberfield,Andrew J. Turberfield +12 more
TL;DR: A family of DNA tetrahedra, less than 10 nanometers on a side, that can self-assemble in seconds with near-quantitative yield of one diastereomer are reported that can be connected by programmable DNA linkers.
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Deformation and collapse of microtubules on the nanometer scale.
TL;DR: A linear elastic regime that can be described by both thin-shell theory and finite element methods is found, in which microtubules are modeled as hollow tubes, and a nonlinear regime and catastrophic collapse of the microtubule under large loads are found.
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Cell visco-elasticity measured with AFM and optical trapping at sub-micrometer deformations
TL;DR: Analysis of the response of single 3T3 fibroblasts that were indented with a micrometer-sized bead attached to an AFM cantilever at forces from 30–600 pN found that at such small deformations, the elastic modulus of 100 Pa is largely determined by the presence of the actin cortex.
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DNA-mediated anisotropic mechanical reinforcement of a virus
Carolina Carrasco,Aura Carreira,Iwan A. T. Schaap,Pedro A. Serena,Julio Gómez-Herrero,Mauricio G. Mateu,P. J. de Pablo +6 more
TL;DR: Evidence of a mechanism to reinforce the strength of an icosahedral virus by using its genomic DNA as a structural element and evidence of biologically relevant conformational rearrangements of the capsid around pores located at the fivefold symmetry axes suggest that the bound DNA may reinforce the overall stiffness of the viral particle without canceling the conformational changes needed for its infectivity.
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Actin filament turnover drives leading edge growth during myelin sheath formation in the central nervous system
Schanila Nawaz,Schanila Nawaz,Paula Sánchez,Sebastian Schmitt,Sebastian Schmitt,Nicholas Snaidero,Nicholas Snaidero,Miso Mitkovski,Caroline Velte,Caroline Velte,Bastian Rouven Brückner,Ioannis Alexopoulos,Tim Czopka,SangYong Jung,Jeong-Seop Rhee,Andreas Janshoff,Walter Witke,Iwan A. T. Schaap,David A. Lyons,Mikael Simons,Mikael Simons +20 more
TL;DR: It is proposed that F-actin turnover is the driving force in myelin wrapping by regulating repetitive cycles of leading edge protrusion and spreading.