J
J. B. Richards
Researcher at King's College London
Publications - 7
Citations - 1007
J. B. Richards is an academic researcher from King's College London. The author has contributed to research in topics: Osteoporosis & Bone mineral. The author has an hindex of 6, co-authored 7 publications receiving 954 citations.
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Journal ArticleDOI
Bone mineral density, osteoporosis, and osteoporotic fractures : a genome-wide association study
J. B. Richards,Fernando Rivadeneira,Michael Inouye,Tomi Pastinen,Nicole Soranzo,Scott Wilson,Scott Wilson,Toby Andrew,Mario Falchi,Rhian Gwilliam,Kourosh R. Ahmadi,Ana M. Valdes,P. Arp,Pamela Whittaker,Dominique J. Verlaan,Dominique J. Verlaan,Mila Jhamai,Vasudev Kumanduri,M. Moorhouse,J.B. van Meurs,Albert Hofman,Huib A.P. Pols,D Hart,Guangju Zhai,Bernet S. Kato,Benjamin H. Mullin,Feng Zhang,Panos Deloukas,André G. Uitterlinden,Tim D. Spector +29 more
TL;DR: The combined effect of these risk alleles on fractures is similar to that of most well-replicated environmental risk factors, and they are present in more than one in five white people, suggesting a potential role in screening.
Journal ArticleDOI
Telomere length in leukocytes correlates with bone mineral density and is shorter in women with osteoporosis
Ana M. Valdes,J. B. Richards,J. P. Gardner,Rami Swaminathan,Masayuki Kimura,L. Xiaobin,Abraham Aviv,Tim D. Spector +7 more
TL;DR: Evidence is provided that leukocyte telomere length could be a marker of biological aging of bone in women and associated with a decrease in BMD and the presence of osteoporosis in women.
Journal ArticleDOI
Homocysteine levels and leukocyte telomere length.
J. B. Richards,Ana M. Valdes,J. P. Gardner,Bernet S. Kato,A. Siva,Masayuki Kimura,Xiaobin Lu,Morris J. Brown,Abraham Aviv,Tim D. Spector +9 more
TL;DR: Increased homocysteine levels are associated with shortened LTL, further supporting the tenet that LTL is an index of cardiovascular risk.
Journal ArticleDOI
A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium
Guangju Zhai,J.B. van Meurs,Gregory Livshits,Ingrid Meulenbelt,Ana M. Valdes,Nicole Soranzo,Deborah J. Hart,Feng Zhang,Bernet S. Kato,J. B. Richards,Frances M K Williams,Michael Inouye,M. Kloppenburg,Panagiotis Deloukas,Eline Slagboom,André G. Uitterlinden,Tim D. Spector +16 more
TL;DR: This study found that the same allele of the SNP significantly reduced bone density at both the hip and spine (p<0.01), suggesting the potential mechanism of the gene in hand OA might be via effects on subchondral bone.
Journal ArticleDOI
Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study
Guangju Zhai,Deborah J. Hart,Ana M. Valdes,Bernet S. Kato,J. B. Richards,Allan Hakim,Tim D. Spector +6 more
TL;DR: This large population-based longitudinal study demonstrated that the decline of BMD over 15 years is linear with age for the FN, but quadratic for the LS, and confirmed the protective role of HRT, increased weight and lean mass in long-term bone loss.