E
Eline Slagboom
Researcher at Leiden University
Publications - 46
Citations - 2353
Eline Slagboom is an academic researcher from Leiden University. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 21, co-authored 46 publications receiving 2099 citations. Previous affiliations of Eline Slagboom include Leiden University Medical Center & Loyola University Medical Center.
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Journal ArticleDOI
Genome-wide association scan for five major dimensions of personality.
Antonio Terracciano,Serena Sanna,Manuela Uda,Barbara Deiana,Gianluca Usala,Fabio Busonero,Andrea Maschio,Matthew Scally,Nicholas S. Patriciu,Wei-Min Chen,Marijn A. Distel,Eline Slagboom,Dorret I. Boomsma,Sandra Villafuerte,Sandra Villafuerte,Elżbieta Śliwerska,Margit Burmeister,Margit Burmeister,Najaf Amin,A. C. J. W. Janssens,C M van Duijn,David Schlessinger,Gonçalo R. Abecasis,Paul T. Costa +23 more
TL;DR: It is inferred that a large number of loci may influence personality traits and disorders, requiring larger sample sizes for the GWA approach to confidently identify associated genetic variants.
Journal ArticleDOI
Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism
Marine Germain,Marine Germain,Marine Germain,Daniel I. Chasman,Hugoline G. de Haan,Weihong Tang,Sara Lindström,Lu-Chen Weng,Mariza de Andrade,Marieke C H De Visser,Kerri L. Wiggins,Pierre Suchon,Noémie Saut,David M. Smadja,Grégoire Le Gal,Astrid van Hylckama Vlieg,Antonio Fabio Di Narzo,Ke Hao,Christopher P. Nelson,Christopher P. Nelson,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Ares Rocanin-Arjo,Lasse Folkersen,Ramin Monajemi,Lynda M. Rose,Jennifer A. Brody,Eline Slagboom,Dylan Aïssi,Dylan Aïssi,Dylan Aïssi,Jean-François Deleuze,Panos Deloukas,Christophe Tzourio,Jean-François Dartigues,Claudine Berr,Kent D. Taylor,Mete Civelek,Per Eriksson,Bruce M. Psaty,Jeanine Houwing-Duitermaat,Alison H. Goodall,Alison H. Goodall,François Cambien,François Cambien,François Cambien,Peter Kraft,Philippe Amouyel,Nilesh J. Samani,Nilesh J. Samani,Saonli Basu,Paul M. Ridker,Frits R. Rosendaal,Christopher Kabrhel,Aaron R. Folsom,John A. Heit,Pieter H. Reitsma,David-Alexandre Trégouët,David-Alexandre Trégouët,David-Alexandre Trégouët,Nicholas L. Smith,Pierre-Emmanuel Morange +61 more
TL;DR: A meta-analysis of genome-wide association studies to identify additional VTE susceptibility genes uncovered unexpected actors of VTE etiology and pave the way for novel mechanistic concepts of V TE pathophysiology.
Journal ArticleDOI
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
Hanneke J. M. Kerkhof,Rik Lories,Ingrid Meulenbelt,Ingileif Jonsdottir,Ana M. Valdes,Pascal P. Arp,Thorvaldur Ingvarsson,Mila Jhamai,Helgi Jonsson,Lisette Stolk,Gudmar Thorleifsson,Guangju Zhai,Feng Zhang,Yanyan Zhu,Ruud van der Breggen,Andrew Carr,Michael Doherty,Sally Doherty,David T. Felson,Antonio Gonzalez,Bjarni V. Halldorsson,Deborah J. Hart,Valdimar B. Hauksson,Albert Hofman,John P. A. Ioannidis,John P. A. Ioannidis,Margreet Kloppenburg,Nancy E Lane,John Loughlin,Frank P. Luyten,Michael C. Nevitt,Neeta Parimi,Huibert A. P. Pols,Fernando Rivadeneira,Eline Slagboom,Unnur Styrkarsdottir,Aspasia Tsezou,Tom Van de Putte,Joseph M. Zmuda,Tim D. Spector,Kari Stefansson,André G. Uitterlinden,Joyce B. J. van Meurs +42 more
TL;DR: A novel common variant on chromosome 7q22 that influences susceptibility to prevalence and progression of OA is identified, since the GPR22 gene encodes a G protein-coupled receptor, this is potentially an interesting therapeutic target.
Journal ArticleDOI
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function
Eleonora Porcu,Marco Medici,Giorgio Pistis,Claudia B. Volpato,Scott Wilson,Anne R. Cappola,Steffan D. Bos,Joris Deelen,Martin den Heijer,Rachel M. Freathy,Jari Lahti,Chunyu Liu,Lorna M. Lopez,Ilja M. Nolte,Jeffrey R. O'Connell,Toshiko Tanaka,Stella Trompet,Alice M. Arnold,Stefania Bandinelli,Marian Beekman,Stefan Böhringer,Suzanne J. Brown,Brendan M. Buckley,Clara Camaschella,Anton J. M. de Craen,Gail Davies,Marieke de Visser,Ian Ford,Tom Forsén,Timothy M. Frayling,Laura Fugazzola,Martin Gögele,Andrew T. Hattersley,Ad R. M. M. Hermus,Albert Hofman,Jeanine J. Houwing-Duistermaat,Richard A. Jensen,Eero Kajantie,Margreet Kloppenburg,Ee Mun Lim,Corrado Masciullo,Stefano Mariotti,Cosetta Minelli,Braxton D. Mitchell,Ramaiah Nagaraja,Romana T. Netea-Maier,Aarno Palotie,Luca Persani,Maria Grazia Piras,Bruce M. Psaty,Katri Räikkönen,J. Brent Richards,Fernando Rivadeneira,Cinzia Sala,Mona M. Sabra,Naveed Sattar,Beverley M. Shields,Nicole Soranzo,John M. Starr,David J. Stott,Fred C.G.J. Sweep,Gianluca Usala,Melanie M. van der Klauw,Diana van Heemst,Alies A. van Mullem,Sita H. Vermeulen,W. Edward Visser,John P. Walsh,Rudi G. J. Westendorp,Elisabeth Widen,Guangju Zhai,Francesco Cucca,Ian J. Deary,Johan G. Eriksson,Luigi Ferrucci,Caroline S. Fox,J. Wouter Jukema,Lambertus A. Kiemeney,Peter P. Pramstaller,David Schlessinger,Alan R. Shuldiner,Eline Slagboom,André G. Uitterlinden,Bijay Vaidya,Theo J. Visser,Bruce H. R. Wolffenbuttel,Ingrid Meulenbelt,Jerome I. Rotter,Tim D. Spector,Andrew A. Hicks,Daniela Toniolo,Serena Sanna,Robin P. Peeters,Silvia Naitza +93 more
TL;DR: A large meta-analysis of genome-wide association studies for serum levels of the highly heritable thyroid function markers TSH and FT4 improves the current knowledge of the regulation of hypothalamic-pituitary-thyroid axis function and the consequences of genetic variation for hypo- or hyperthyroidism.
Journal ArticleDOI
Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans.
Evelyna Derhovanessian,Andrea B. Maier,Karin Hähnel,Robert Beck,Anton J. M. de Craen,Eline Slagboom,Rudi G. J. Westendorp,Graham Pawelec +7 more
TL;DR: It is concluded that hallmarks of age-associated alterations to immune signatures are indeed observed in the general population in people infected with CMV and not those infected with a different persistent herpesvirus.