J. David Lawson

TL;DR: The data suggest that intrinsically unstructured proteins play key roles in cell-signaling, regulation and cancer, where coupled folding and binding is a common mechanism.

TL;DR: The distinctive amino acid biases of high‐B‐factor ordered regions, short disordered regions, and long dis ordered regions indicate that the sequence determinants for these flexibility categories differ from one another, whereas the significantly‐greater‐than‐chance predictability of these categories from sequence suggest that flexible ordered regions and short disorder are, to a significant degree, encoded at the primary structure level.

TL;DR: The Database of Protein Disorder (DisProt) is a curated database that provides structure and function information about proteins that lack a fixed three-dimensional structure under putatively native conditions, either in their entirety or in part.

TL;DR: The discovery and optimization of a series of 4-aminocinnoline-3-carboxamide inhibitors of Bruton's tyrosine kinase are reported, resulting in the identification of a lead compound which reduced paw swelling in a dose- and exposure-dependent fashion in a rat model of collagen-induced arthritis.