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Journal ArticleDOI

Intrinsic Disorder and Protein Function

A. Keith Dunker, +4 more
- 01 May 2002 - 
- Vol. 41, Iss: 21, pp 6573-6582
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This article is published in Biochemistry.The article was published on 2002-05-01. It has received 1634 citations till now. The article focuses on the topics: Protein folding & Clusterin.

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Citations
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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Intrinsically unstructured proteins and their functions.

H. Jane Dyson, +1 more
- 01 Mar 2005 - 
TL;DR: Many gene sequences in eukaryotic genomes encode entire proteins or large segments of proteins that lack a well-structured three-dimensional fold, whereas others constitute flexible linkers that have a role in the assembly of macromolecular arrays.
Journal ArticleDOI

How to study proteins by circular dichroism

Sharon M. Kelly, +2 more
- 10 Aug 2005 - 
TL;DR: The basis of the CD approach and its application to the study of proteins, and clear guidelines on how reliable data can be obtained and analysed are presented.
Journal ArticleDOI

Intrinsically unstructured proteins.

Peter Tompa
- 01 Oct 2002 - 
TL;DR: In this review, recent findings are surveyed to illustrate that this novel but rapidly advancing field has reached a point where proteins can be comprehensively classified on the basis of structure and function.
Journal ArticleDOI

Prediction and functional analysis of native disorder in proteins from the three kingdoms of life.

Jonathan J. Ward, +4 more
- 26 Mar 2004 - 
TL;DR: An automatic method for recognizing natively disordered regions from amino acid sequence is described and benchmarked against predictors that were assessed at the latest critical assessment of techniques for protein structure prediction (CASP) experiment and represents a statistically significant improvement on the methods evaluated on the same targets at CASP.
References
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Book

Basic methods in molecular biology

L. G. Davis, +2 more
TL;DR: General methods bacterial strains and cloning vectors enzymes that modify DNA and RNA in vitro amplification of DNA using the polymerase chain reaction (PCR) and the thermostable Taq DNA polymerase, introduction DNA restriction fragment analysis and preparation.
Journal ArticleDOI

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

Kazuhito Yamamoto, +2 more
- 01 Dec 1999 - 
TL;DR: Stress response kinases phosphorylate BCL-2 during cell cycle progression as a normal physiologic process to inactivate B CL-2 at G2/M.
Journal ArticleDOI

Intrinsic protein disorder in complete genomes.

A.K. Dunker, +4 more
- 01 Jan 2000 - 
TL;DR: Overall, intrinsic disorder appears to be a common, with eucaryotes perhaps having a higher percentage of native disorder than archaea or bacteria, and bacteria and archaea in various archaea ranged from 2 to 11%, plus an apparently anomalous 18% in bacteria.
Book

Of urfs and orfs : a primer on how to analyze devised amino acid sequences

Russell F. Doolittle
TL;DR: Searching through data banks So you found something!
Journal ArticleDOI

The Conformation of Histone H5 Isolation and Characterisation of the Globular Segment

Francisco J. Aviles, +4 more
- 01 Aug 1978 - 
TL;DR: It is concluded that the resistant peptide, GH5, represents a globular folded region of the molecule whilst the rapidly digested parts are disordered and remains all the alpha-helical structure of intact H5 and appears to also maintain all the tertiary structure.
Related Papers (5)

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.

Peter E. Wright, +1 more
- 22 Oct 1999 - 

Intrinsically unstructured proteins and their functions.

H. Jane Dyson, +1 more
- 01 Mar 2005 - 

Intrinsically unstructured proteins.

Peter Tompa
- 01 Oct 2002 - 

Why are "natively unfolded" proteins unstructured under physiologic conditions?

Vladimir N. Uversky, +3 more
- 15 Nov 2000 - 

Natively unfolded proteins: a point where biology waits for physics.

Vladimir N. Uversky
- 01 Apr 2002 -