J
J. E. Collins
Researcher at University of Birmingham
Publications - 6
Citations - 808
J. E. Collins is an academic researcher from University of Birmingham. The author has contributed to research in topics: Single-nucleotide polymorphism & Graves' disease. The author has an hindex of 6, co-authored 6 publications receiving 792 citations.
Papers
More filters
Journal ArticleDOI
Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus
Deborah J. Smyth,Jason D. Cooper,J. E. Collins,Joanne M. Heward,Jayne A. Franklyn,Joanna M. M. Howson,Adrian Vella,Sarah Nutland,Helen E. Rance,Lisa M. Maier,Bryan J. Barratt,Cristian Guja,Constantin Ionescu-Tirgoviste,David A. Savage,David B. Dunger,Barry Widmer,David P. Strachan,Susan M. Ring,Neil Walker,David Clayton,Rebecca C.J. Twells,Stephen C. L. Gough,John A. Todd +22 more
TL;DR: A more general association of the PTPN22 locus with autoimmune disease is indicated, as reported for an association of Trp(620) with another autoimmune disorder, Graves' disease, in 1,734 case and control subjects.
Journal ArticleDOI
Association of the TSHR gene with Graves' disease: the first disease specific locus
Bryan M. Dechairo,Delilah Zabaneh,J. E. Collins,Oliver J. Brand,Gary Dawson,Angie P Green,Ian Mackay,Jayne A. Franklyn,John M. C. Connell,John Wass,Wilmar M. Wiersinga,Laszlo Hegedüs,Thomas Heiberg Brix,Bruce G. Robinson,Penny J. Hunt,Anthony P. Weetman,Alisoun H. Carey,Stephen C. L. Gough +17 more
TL;DR: The linkage disequilibrium structure encompassing the TSHR is analysed, to identify LD ‘blocks’ and SNPs, which capture the majority of intra-block haplotype diversity and suggest that the T SHR is the first replicated GD-specific locus meriting further fine mapping and functional analysis to identify the aetiological variants.
Journal ArticleDOI
Autoimmunity in thyroid disease.
TL;DR: This review will focus on some of the studies designed to identify genes that confer susceptibility to the autoimmune disease process within the thyroid gland.
Journal ArticleDOI
Lack of association of the vitamin D receptor gene with Graves' disease in UK Caucasians.
J. E. Collins,Joanne M. Heward,R. Nithiyananthan,Sergey Nejentsev,John A. Todd,Jayne A. Franklyn,Stephen C. L. Gough +6 more
TL;DR: The aim of this study was to test for association of polymorphisms of the VDR gene in the genetic susceptibility to GD in UK Caucasians.
Journal ArticleDOI
Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom.
J. E. Collins,Joanne M. Heward,Joanna M. M. Howson,Helen Foxall,J. Carr-Smith,Jayne A. Franklyn,Stephen C. L. Gough +6 more
TL;DR: In the largest case-control association study to date with adequate power to detect the reported effect if present, it is found that the recently identified single nucleotide polymorphisms do not have a causal role for AITD in the UK.