J
Jason D. Cooper
Researcher at University of Cambridge
Publications - 112
Citations - 18007
Jason D. Cooper is an academic researcher from University of Cambridge. The author has contributed to research in topics: Single-nucleotide polymorphism & Genome-wide association study. The author has an hindex of 50, co-authored 112 publications receiving 16737 citations. Previous affiliations of Jason D. Cooper include JDRF & McGill University.
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Journal ArticleDOI
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
Jeffrey C. Barrett,David Clayton,Patrick Concannon,Beena Akolkar,Jason D. Cooper,Henry A. Erlich,Cécile Julier,Grant Morahan,Jørn Nerup,Concepcion Nierras,Vincent Plagnol,Flemming Pociot,Helen Schuilenburg,Deborah J. Smyth,Helen Stevens,John A. Todd,Neil Walker,Stephen S. Rich +17 more
TL;DR: The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.
Journal ArticleDOI
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd,Neil Walker,Jason D. Cooper,Deborah J. Smyth,Kate Downes,Vincent Plagnol,Rebecca Bailey,Sergey Nejentsev,Sarah F. Field,Felicity Payne,Christopher E. Lowe,Jeffrey S. Szeszko,Jason P. Hafler,Lauren R. Zeitels,Jennie H M Yang,Adrian Vella,Adrian Vella,Sarah Nutland,Helen Stevens,Helen Schuilenburg,Gillian Coleman,Meeta Maisuria,William Meadows,Luc J. Smink,Barry C. Healy,Oliver S. Burren,Alex C. Lam,Nigel R. Ovington,James E. Allen,Ellen C. Adlem,H. T. Leung,Chris Wallace,Joanna M. M. Howson,Cristian Guja,Constantin Ionescu-Tirgoviste,Matthew J. Simmonds,Joanne M. Heward,Stephen C. L. Gough,David B. Dunger,Linda S. Wicker,David Clayton +40 more
TL;DR: This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease.
Journal ArticleDOI
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
Thomas J. Wang,Feng Zhang,J. Brent Richards,Bryan Kestenbaum,Joyce B. J. van Meurs,Diane J. Berry,Douglas P. Kiel,Elizabeth A. Streeten,Claes Ohlsson,Daniel L. Koller,Leena Peltonen,Leena Peltonen,Jason D. Cooper,Paul F. O'Reilly,Denise K. Houston,Nicole L. Glazer,Liesbeth Vandenput,Munro Peacock,Julia Shi,Fernando Rivadeneira,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Pouta Anneli,Ian H. de Boer,Massimo Mangino,Bernet S. Kato,Deborah J. Smyth,Sarah L. Booth,Paul F. Jacques,Greg L. Burke,Mark O. Goodarzi,Ching-Lung Cheung,Myles Wolf,Kenneth Rice,David Goltzman,Nick Hidiroglou,Martin Ladouceur,Nicholas J. Wareham,Lynne J. Hocking,Deborah J. Hart,Nigel K Arden,Cyrus Cooper,Suneil Malik,William D. Fraser,Anna Liisa Hartikainen,Guangju Zhai,Helen M. Macdonald,Nita G. Forouhi,Ruth J. F. Loos,David M. Reid,Alan Hakim,Elaine M. Dennison,Yongmei Liu,Chris Power,Helen Stevens,Laitinen Jaana,Ramachandran S. Vasan,Nicole Soranzo,Nicole Soranzo,Jörg Bojunga,Bruce M. Psaty,Mattias Lorentzon,Tatiana Foroud,Tamara B. Harris,Albert Hofman,John-Olov Jansson,Jane A. Cauley,André G. Uitterlinden,Quince Gibson,Marjo-Riitta Järvelin,David Karasik,David S. Siscovick,Michael J. Econs,Stephen B. Kritchevsky,Jose C. Florez,John A. Todd,Josée Dupuis,Elina Hyppönen,Tim D. Spector +79 more
TL;DR: In this article, a genome-wide association study of 25-hydroxyvitamin D concentrations in 33,996 individuals of European descent from 15 cohorts was conducted to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency.
Journal ArticleDOI
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts.
Karani Santhanakrishnan Vimaleswaran,Diane J. Berry,Emmi Tikkanen,Emmi Tikkanen,Stefan Pilz,Stefan Pilz,Linda T. Hiraki,Jason D. Cooper,Zari Dastani,Denise K. Houston,Andrew R. Wood,Liesbeth Vandenput,Lina Zgaga,Lina Zgaga,Laura M. Yerges-Armstrong,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Marika Kaakinen,Marcus E. Kleber,Kurt Lohman,Luigi Ferrucci,Liisa Byberg,Lars Lind,Mattias Lorentzon,Veikko Salomaa,Harry Campbell,Malcolm G. Dunlop,Malcolm G. Dunlop,Braxton D. Mitchell,Karl-Heinz Herzig,Elizabeth A. Streeten,Evropi Theodoratou,Antti Jula,Nicholas J. Wareham,Claes Ohlsson,Timothy M. Frayling,Stephen B. Kritchevsky,Tim D. Spector,J. Brent Richards,J. Brent Richards,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Peter Kraft,Cyrus Cooper,Chris Power,Ruth J. F. Loos,Thomas J. Wang,John C. Whittaker,John C. Whittaker,Aroon D. Hingorani,Elina Hyppönen +52 more
TL;DR: A mendelian randomization study based on data from multiple cohorts conducted by Karani Santhanakrishnan Vimaleswaran and colleagues re-examines the causal nature of the relationship between vitamin D levels and obesity.
Journal ArticleDOI
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Nicholas John Craddock,Matthew E. Hurles,Niall Cardin,Richard D. Pearson,Vincent Plagnol,Samuel Robson,Damjan Vukcevic,Chris P. Barnes,Donald F. Conrad,Eleni Giannoulatou,Christopher Holmes,Jonathan Marchini,Kathy Stirrups,Martin D. Tobin,Louise V. Wain,Christopher Yau,Jan Aerts,Tariq Ahmad,T. Daniel Andrews,Hazel Arbury,Anthony Attwood,Anthony Attwood,Anthony Attwood,Adam Auton,Stephen G. Ball,Anthony J. Balmforth,Jeffrey C. Barrett,Inês Barroso,Anne Barton,Amanda J. Bennett,Sanjeev S. Bhaskar,Katarzyna Blaszczyk,John Bowes,Oliver J. Brand,Peter S. Braund,Francesca Bredin,Gerome Breen,Gerome Breen,Morris J. Brown,Ian N. Bruce,Jaswinder Bull,Oliver S. Burren,John Burton,Jake K. Byrnes,Sian Caesar,Chris Clee,Alison J. Coffey,John M. C. Connell,Jason D. Cooper,Anna F. Dominiczak,Kate Downes,Hazel E. Drummond,Darshna Dudakia,Andrew Dunham,Bernadette Ebbs,Diana Eccles,Sarah Edkins,Cathryn Edwards,Anna Elliot,Paul Emery,David M. Evans,Gareth Evans,Steve Eyre,Anne Farmer,I. Nicol Ferrier,Lars Feuk,Lars Feuk,Tomas W Fitzgerald,Edward Flynn,Alistair Forbes,Liz Forty,Jayne A. Franklyn,Jayne A. Franklyn,Rachel M. Freathy,Polly Gibbs,Paul Gilbert,Omer Gokumen,Katherine Gordon-Smith,Katherine Gordon-Smith,Emma Gray,Elaine K. Green,Christopher J. Groves,Detelina Grozeva,Rhian Gwilliam,A Hall,Naomi Hammond,Matthew Hardy,Pile Harrison,Neelam Hassanali,Husam Hebaishi,Sarah Hines,Anne Hinks,Graham A. Hitman,Lynne J. Hocking,Eleanor Howard,Philip Howard,Joanna M. M. Howson,Debbie Hughes,Sarah E. Hunt,John D. Isaacs,Mahim Jain,Derek P. Jewell,Toby Johnson,Jennifer Jolley,Jennifer Jolley,Ian Jones,Lisa Jones,George Kirov,Cordelia Langford,Hana Lango-Allen,G. Mark Lathrop,James Lee,Kate L. Lee,Charlie W. Lees,Kevin Lewis,Cecilia M. Lindgren,Meeta Maisuria-Armer,Julian Maller,John C. Mansfield,Paul Martin,Dunecan Massey,Wendy L. McArdle,Peter McGuffin,Kirsten McLay,Alexander J. Mentzer,Michael L. Mimmack,Ann E. Morgan,Andrew P. Morris,Craig Mowat,Simon Myers,William G. Newman,Elaine R. Nimmo,Michael Conlon O'Donovan,Abiodun Onipinla,Ifejinelo Onyiah,Nigel R. Ovington,Michael John Owen,Kimmo Palin,Kirstie Parnell,David Pernet,John R. B. Perry,Anne M. Phillips,Dalila Pinto,Natalie J. Prescott,Inga Prokopenko,Michael A. Quail,Suzanne Rafelt,Nigel W. Rayner,Richard Redon,David M. Reid,Anthony Renwick,Susan M. Ring,Neil Robertson,E. Russell,David St Clair,Jennifer G. Sambrook,Jennifer G. Sambrook,Jeremy D. Sanderson,Helen Schuilenburg,Carol Scott,Richard T. Scott,Sheila Seal,Sue Shaw-Hawkins,Beverley M. Shields,Matthew J. Simmonds,Debbie J. Smyth,Elilan Somaskantharajah,Katarina Spanova,Sophia Steer,Jonathan Stephens,Jonathan Stephens,Helen Stevens,Millicent A. Stone,Millicent A. Stone,Zhan Su,Deborah P M Symmons,John R. Thompson,Wendy Thomson,Mary E. Travers,Clare Turnbull,Armand Valsesia,Mark Walker,Neil Walker,Chris Wallace,Margaret Warren-Perry,Nicholas A. Watkins,Nicholas A. Watkins,John Webster,Michael N. Weedon,Anthony G. Wilson,Matthew Woodburn,B. Paul Wordsworth,Allan H. Young,Allan H. Young,Eleftheria Zeggini,Eleftheria Zeggini,Nigel P. Carter,Timothy M. Frayling,Charles Lee,Gil McVean,Patricia B. Munroe,Aarno Palotie,Stephen Sawcer,Stephen W. Scherer,David P. Strachan,Chris Tyler-Smith,Matthew A. Brown,Matthew A. Brown,Paul Burton,Mark J. Caulfield,Alastair Compston,Martin Farrall,Stephen C. L. Gough,Stephen C. L. Gough,Alistair S. Hall,Andrew T. Hattersley,Adrian V. S. Hill,Christopher G. Mathew,Marcus Pembrey,Jack Satsangi,Michael R. Stratton,Jane Worthington,Panos Deloukas,Audrey Duncanson,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Mark I. McCarthy,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Miles Parkes,Nazneen Rahman,John A. Todd,Nilesh J. Samani,Nilesh J. Samani,Peter Donnelly +235 more
TL;DR: A large, direct genome-wide study of association between CNVs and eight common human diseases concludes that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis ofcommon human diseases.