S
Sergey Nejentsev
Researcher at University of Cambridge
Publications - 66
Citations - 9194
Sergey Nejentsev is an academic researcher from University of Cambridge. The author has contributed to research in topics: Tuberculosis & Single-nucleotide polymorphism. The author has an hindex of 37, co-authored 62 publications receiving 7948 citations. Previous affiliations of Sergey Nejentsev include Children's Mercy Hospital & University of Amsterdam.
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Journal ArticleDOI
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
John A. Todd,Neil Walker,Jason D. Cooper,Deborah J. Smyth,Kate Downes,Vincent Plagnol,Rebecca Bailey,Sergey Nejentsev,Sarah F. Field,Felicity Payne,Christopher E. Lowe,Jeffrey S. Szeszko,Jason P. Hafler,Lauren R. Zeitels,Jennie H M Yang,Adrian Vella,Adrian Vella,Sarah Nutland,Helen Stevens,Helen Schuilenburg,Gillian Coleman,Meeta Maisuria,William Meadows,Luc J. Smink,Barry C. Healy,Oliver S. Burren,Alex C. Lam,Nigel R. Ovington,James E. Allen,Ellen C. Adlem,H. T. Leung,Chris Wallace,Joanna M. M. Howson,Cristian Guja,Constantin Ionescu-Tirgoviste,Matthew J. Simmonds,Joanne M. Heward,Stephen C. L. Gough,David B. Dunger,Linda S. Wicker,David Clayton +40 more
TL;DR: This study increases the number of T1D loci with compelling evidence from six to at least ten, with evidence for chromosome 18q22 and 18p11, which showed association with autoimmune thyroid disease.
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Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.
TL;DR: This work resequenced exons and splice sites of 10 candidate genes in pools of DNA from 480 patients and 480 controls and tested their disease association in over 30,000 participants to establish the role of IFIH1 and demonstrate that resequencing studies can pinpoint disease-causing genes in genomic regions initially identified by GWASs.
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A robust model for read count data in exome sequencing experiments and implications for copy number variant calling
Vincent Plagnol,James Curtis,Michael Epstein,Kin Y. Mok,Emma Stebbings,Sofia Grigoriadou,Nicholas W. Wood,Sophie Hambleton,Siobhan O. Burns,Adrian J. Thrasher,Dinakantha S. Kumararatne,Rainer Doffinger,Sergey Nejentsev +12 more
TL;DR: This analysis identified two novel causative deletions in the genes GATA2 and DOCK8 and introduced ExomeDepth, a new CNV calling algorithm designed to control for technical variability between samples in exome sequence data.
Journal ArticleDOI
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
Sergey Nejentsev,Joanna M. M. Howson,Neil Walker,Jeffrey S. Szeszko,Sarah F. Field,Helen Stevens,Pamela Reynolds,Matthew Hardy,Erna King,Jennifer Masters,John S. Hulme,Lisa M. Maier,Deborah J. Smyth,Rebecca Bailey,Jason D. Cooper,Gloria Ribas,R. Duncan Campbell,David Clayton,John A. Todd,Paul Burton,Lon R. Cardon,Nicholas John Craddock,Panos Deloukas,Audrey Duncanson,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Mark I. McCarthy,Willem H. Ouwehand,Willem H. Ouwehand,Nilesh J. Samani,Peter Donnelly,Jeffrey C. Barrett,Dan Davison,Doug Easton,David M. Evans,H. T. Leung,Jonathan Marchini,Andrew P. Morris,Chris C. A. Spencer,Martin D. Tobin,Antony P. Attwood,Antony P. Attwood,James P. Boorman,James P. Boorman,Barbara Cant,Ursula Everson,Judith M. Hussey,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Elizabeth Meech,Sarah Nutland,Christopher Prowse,Niall C. Taylor,Graham R. Walters,Nicholas A. Watkins,Nicholas A. Watkins,Thilo Winzer,Richard Jones,Wendy L. McArdle,Susan M. Ring,David P. Strachan,Marcus Pembrey,Marcus Pembrey,Gerome Breen,David St Clair,Sian Caesar,Katherine Gordon-Smith,Katherine Gordon-Smith,Lisa Jones,Christine Fraser,Elaine K. Green,Detelina Grozeva,Marian L. Hamshere,Peter Holmans,Ian Jones,George Kirov,Valentina Moskvina,Ivan Nikolov,Michael Conlon O'Donovan,Michael John Owen,David A. Collier,Amanda Elkin,Anne Farmer,Richard Williamson,Peter McGuffin,Allan H. Young,I. Nicol Ferrier,Stephen G. Ball,Anthony J. Balmforth,Jennifer H. Barrett,D. Timothy Bishop,Mark M. Iles,Azhar Maqbool,Nadira Yuldasheva,Alistair S. Hall,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,John R. Thompson,Francesca Bredin,Mark Tremelling,Miles Parkes,Hazel E. Drummond,Charlie W. Lees,Elaine R. Nimmo,Jack Satsangi,Sheila A. Fisher,Alastair Forbes,Cathryn M. Lewis,Clive M. Onnie,Natalie J. Prescott,Jeremy D. Sanderson,Christopher G. Mathew,Jamie Barbour,M. Khalid Mohiuddin,Catherine E. Todhunter,John C. Mansfield,Tariq Ahmad,Fraser Cummings,Derek P. Jewell,John Webster,Morris J. Brown,G. Mark Lathrop,John M. C. Connell,Anna F. Dominiczak,Carolina A. Braga,Beverley Burke,Richard Dobson,Johannie Gungadoo,Kate L. Lee,Patricia B. Munroe,Stephen Newhouse,Abiodun Onipinla,Chris Wallace,Mingzhan Xue,Mark J. Caulfield,Martin Farrall,Anne Barton,Ian N. Bruce,Hannah Donovan,Steve Eyre,Paul D. Gilbert,Samantha L. Hider,Anne Hinks,Sally John,Catherine Potter,Alan J. Silman,Deborah P M Symmons,Wendy Thomson,Jane Worthington,David B. Dunger,Barry Widmer,Timothy M. Frayling,Rachel M. Freathy,Hana Lango,John R. B. Perry,Beverley M. Shields,Michael N. Weedon,Andrew T. Hattersley,Graham A. Hitman,Mark Walker,Kate S. Elliott,Christopher J. Groves,Cecilia M. Lindgren,Nigel W. Rayner,Nicholas J. Timpson,Nicholas J. Timpson,Eleftheria Zeggini,Melanie J. Newport,Giorgio Sirugo,Emily J. Lyons,Fredrik O. Vannberg,Adrian V. S. Hill,Linda A. Bradbury,C Farrar,J J Pointon,Paul Wordsworth,Matthew A. Brown,Matthew A. Brown,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C. L. Gough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Maria Ban,An Goris,Stephen Sawcer,Alastair Compston,David J. Conway,Muminatou Jallow,Kirk A. Rockett,Claire Bryan,Suzannah Bumpstead,Amy Chaney,Kate Downes,Kate Downes,Jilur Ghori,Rhian Gwilliam,Sarah E. Hunt,Michael Inouye,Andrew Keniry,Emma King,Ralph McGinnis,Simon C. Potter,Rathi Ravindrarajah,Pamela Whittaker,David Withers,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingeleif B. Hallgrimsdottir,Bryan Howie,Zhan Su,Yik Ying Teo,Damjan Vukcevic,David Bentley,David Bentley,A Compston +221 more
TL;DR: In this article, the major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune.
Journal ArticleDOI
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage
Ivan Angulo,Oscar Vadas,Fabien Garçon,Edward Banham-Hall,Vincent Plagnol,Timothy Ronan Leahy,Timothy Ronan Leahy,Helen Baxendale,Tanya I. Coulter,Tanya I. Coulter,James Curtis,Changxin Wu,Katherine G. Blake-Palmer,Olga Perisic,Deborah J. Smyth,Mailis Maes,Christine A Fiddler,Jatinder K. Juss,Deirdre Cilliers,Gašper Markelj,Anita Chandra,George Farmer,Anna Kielkowska,Jonathan Clark,Sven Kracker,Sven Kracker,Marianne Debré,Capucine Picard,Capucine Picard,Isabelle Pellier,Nada Jabado,James Morris,Gabriela Barcenas-Morales,Alain Fischer,Alain Fischer,Len R. Stephens,Phillip T. Hawkins,Jeffrey C. Barrett,Mario Abinun,Menna R. Clatworthy,Anne Durandy,Rainer Doffinger,Edwin R. Chilvers,Andrew J. Cant,Dinakantha S. Kumararatne,Klaus Okkenhaug,Roger L. Williams,Alison M. Condliffe,Sergey Nejentsev +48 more
TL;DR: Activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-of-function mutation in which lysine replaced glutamic acid at residue 1021 (E1021K) in the p110δ protein, the catalytic subunit of phosphoinositide 3-kinase δ (PI3Kδ), encoded by the PIK3CD gene is described.