J. L. Garces

TL;DR: The results show that bistable behavior in covalent modification cascades relies not only on the structure and regulatory pattern of feedback/feedforward loops, but also on the kinetic characteristics of their component proteins.

TL;DR: AGNES (absence of gradients and Nernstian equilibrium stripping) is a stripping technique consisting of two conceptual steps: (i) application of a potential program (e.g. a step at a fixed potential) generating a known concentration gain between the outer and inner concentrations of the metal at the mercury electrode surface together with null gradients of the concentration profiles (inside and outside the mercury electrodes) and (ii) determination of the reduced metal inside the amalgam in a stripping step as mentioned in this paper.

TL;DR: In this paper, the steady-state flux arriving at an active surface from a mixture (in which one active species reacts with non-active ligands in the medium) can be characterized in terms of a list of dimensionless parameters involving the kinetic and mobility properties of each species.

TL;DR: The approach combines the classical rotational isomeric state (RIS) model developed by Flory and the site binding model used to treat proton binding equilibria to develop the SBRIS model, which treats conformational degrees of freedom and protonbinding on equal footing.

TL;DR: It is shown that, because of the mixture effect, the lability of a given complex usually increases when another more labile complex is added into the system, while it decreases upon addition of a less labile one.