J. Simon C. Arthur

TL;DR: Harmine has been identified as a potent and specific inhibitor of DYRK1A (dual-specificity tyrosine-phosphorylated and -regulated kinase 1A) in vitro and the results have further emphasized the need for considerable caution in using small-molecule inhibitors of protein kinases to assess the physiological roles of these enzymes.

TL;DR: This Review discusses the current knowledge about the regulation and the function of MAPKs in innate immunity, as well as the importance of negative feedback loops in limiting MAPK activity to prevent host tissue damage and how pathogens have evolved complex mechanisms to manipulate MAPK activation to increase their virulence.

TL;DR: It is concluded that MSKs are the major kinases for histone H3 and HMG‐14 in response to mitogenic and stress stimuli in fibroblasts.

TL;DR: PDK1 mediates activation of PKB, p70 S6 kinase and p90 Rsk in vivo, but is not rate-limiting foractivation of PKA, MSK1 and AMPK.

TL;DR: It is shown that MSK1 and MSK2 are required for the stress-induced phosphorylation of transcription factors CREB and ATF1 in primary embryonic fibroblasts, which results in a 50% reduction in c-fos and junB gene transcription in response to anisomycin or UV-C radiation.