J
J. T. Wijnen
Researcher at Loyola University Medical Center
Publications - 26
Citations - 1943
J. T. Wijnen is an academic researcher from Loyola University Medical Center. The author has contributed to research in topics: Colorectal cancer & Familial adenomatous polyposis. The author has an hindex of 15, co-authored 26 publications receiving 1823 citations. Previous affiliations of J. T. Wijnen include Newcastle University.
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Journal ArticleDOI
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.
Hans F. A. Vasen,J. T. Wijnen,Fred H. Menko,Jan H. Kleibeuker,B. G. Taal,Gerrit Griffioen,Fokko M. Nagengast,E. H. Meijers-Heijboer,Lucio Bertario,L. Varesco,Marie Luise Bisgaard,J. Mohr,Riccardo Fodde,P M Khan +13 more
TL;DR: Estimates of cancer risk that may contribute to the appropriate management of gene carriers within families with hereditary nonpolyposis colorectal cancer are provided.
Journal ArticleDOI
MSH2 mutation carriers are at higher risk of cancer than MLH1 mutation carriers : A study of hereditary nonpolyposis colorectal cancer families
Hans F. A. Vasen,Astrid Stormorken,Fred H. Menko,Fokko M. Nagengast,Jan H. Kleibeuker,Gerrit Griffioen,B. G. Taal,Peter Möller,J. T. Wijnen +8 more
TL;DR: Pending large prospective studies, the extension of the current surveillance program in MSH2 mutation carriers with the inclusion of the urinary tract should be considered.
Journal ArticleDOI
Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree
Anja Wagner,Yvonne M.C. Hendriks,E.J. Meijers-Heijboer,W. J. F. De Leeuw,Hans Morreau,Robert M.W. Hofstra,C. Tops,E Bik,A H J T Bröcker-Vriends,C. A. Van Der Meer,Dick Lindhout,Hans F. A. Vasen,Martijn H. Breuning,C J Cornelisse,C van Krimpen,M. F. Niermeijer,Aeilko H. Zwinderman,J. T. Wijnen,Riccardo Fodde +18 more
TL;DR: An extended Dutch HNPCC family not fulfilling the Amsterdam criteria II and resulting from a MSH6 mutation is described, confirming that the pattern of microsatellite instability, in combination with immunohistochemical analysis, can predict the presence of aMSH6 germline defect.
PeutzeJeghers syndrome: a systematic review and recommendations for management
A D Beggs,A R Latchford,H F A Vasen,G Moslein,A Alonso,Stefan Aretz,L Bertario,Ignacio Blanco,J Burn,F J Hes,R. K. S. Phillips,W. Hyer,Laura Renkonen-Sinisalo,A Stormorken,S Tejpar,H. J. W. Thomas,J. T. Wijnen,S. K. Clark,Shirley Hodgson +18 more
TL;DR: The proposed guidelines contained in this article have been produced as a consensus statement on behalf of a group of European experts who met in Mallorca in 2007 and who have produced guidelines on the clinical management of Lynch syndrome and familial adenomatous polyposis.
Journal ArticleDOI
Germline variants in POLE are associated with early onset mismatch repair deficient colorectal cancer.
Fadwa A. Elsayed,C. Marleen Kets,Dina Ruano,Brendy E.W.M. van den Akker,Arjen R. Mensenkamp,Melanie Schrumpf,Maartje Nielsen,J. T. Wijnen,Carli M. J. Tops,Marjolijn J. L. Ligtenberg,Hans F. A. Vasen,Frederik J. Hes,Hans Morreau,Tom van Wezel +13 more
TL;DR: POLE DNA analysis now seems warranted in microsatellite instable CRC, especially in the absence of a causative DNA mismatch repair gene germline variant.