G Moslein

TL;DR: The guidelines described herein may be helpful in the appropriate management of FAP families and, in order to improve the care of these families further, prospective controlled studies should be undertaken.

TL;DR: In this article, the authors present guidelines for surveillance and management of individuals with Peutz-Jeghers syndrome (PJS), an autosomal dominant condition defined by the development of characteristic polyps throughout the gastrointestinal tract and mucocutaneous pigmentation.

TL;DR: In this article, the authors present guidelines for the clinical management of families with Lynch syndrome based on a systematic literature search using Pubmed and the Cochrane Database of Systematic Reviews reference lists of retrieved articles.

TL;DR: Hereditary non-polyposis colorectal cancer was shown to be caused by germline mutations in the DNA mismatch repair genes MSH2, MLH1, PMS1,PMS2 and MSH6, and many HNPCC families do not fully comply with the clinical Amsterdam criteria, and the causative mutations are unknown.

TL;DR: Evaluating the strategies currently used to identify individuals at high risk for CRC in 14 Western European countries showed that in all countries obtaining a family history followed by referral to clinical genetics centres of suspected cases was the main strategy to identify familial and hereditary CRC.