L
L. Varesco
Publications - 5
Citations - 1094
L. Varesco is an academic researcher. The author has contributed to research in topics: Colorectal cancer & Gene mutation. The author has an hindex of 5, co-authored 5 publications receiving 1078 citations.
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Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis.
Hans F. A. Vasen,J. T. Wijnen,Fred H. Menko,Jan H. Kleibeuker,B. G. Taal,Gerrit Griffioen,Fokko M. Nagengast,E. H. Meijers-Heijboer,Lucio Bertario,L. Varesco,Marie Luise Bisgaard,J. Mohr,Riccardo Fodde,P M Khan +13 more
TL;DR: Estimates of cancer risk that may contribute to the appropriate management of gene carriers within families with hereditary nonpolyposis colorectal cancer are provided.
Journal Article
Seven new mutations in hMSH2, an HNPCC gene, identified by denaturing gradient-gel electrophoresis.
Juul T. Wijnen,Hans F. A. Vasen,P M Khan,Fh Menko,H Vanderklift,C Vanleeuwen,M Vandenbroek,Vanleeuwencornelisse,F.M. Nagengast,A Meijers-Heijboer,D Lindhout,Gerrit Griffioen,A Cats,Jan H. Kleibeuker,L. Varesco,Lucio Bertario,Ml Bisgaard,J. Mohr,Riccardo Fodde +18 more
TL;DR: The results indicate that, given the genomic size and organization of the hMSH2 gene and the heterogeneity of its mutation spectrum, a rapid and efficient mutation detection procedure is necessary for routine molecular diagnosis and presymptomatic detection of the disease in a clinical setup.
Journal Article
Majority of hMLH1 mutations responsible for hereditary nonpolyposis colorectal cancer cluster at the exonic region 15-16
Juul T. Wijnen,P M Khan,Hans F. A. Vasen,Fred H. Menko,H. van der Klift,M. van den Broek,I. S. J. van Leeuwen-Cornelisse,Fokko N. Nagengast,E. J. Meijers-Heijboer,Dick Lindhout,Gerrit Griffioen,A. Cats,Jan H. Kleibeuker,L. Varesco,Lucio Bertario,Marie Luise Bisgaard,J. Mohr,Richard D. Kolodner,Riccardo Fodde +18 more
TL;DR: While the spectrum of mutations at the hMSH2 gene among HNPCC patients appears heterogeneous, a cluster of hMLH1 mutations has been found in the region encompassing exons 15 and 16, which accounts for 50% of all the independent hMLh1 mutations described to date and for > 20% of the unrelated HNP CC kindreds here analyzed.
Journal Article
Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis (vol 110, pg 1020, 1996)
H. F. A. Vasen,J. T. Wijnen,Fred H. Menko,Jan H. Kleibeuker,B. G. Taal,Gerrit Griffioen,Fokko M. Nagengast,E. H. Meijers-Heijboer,Lucio Bertario,L. Varesco,Marie Luise Bisgaard,J. Mohr,Riccardo Fodde,P M Khan +13 more
Journal Article
Erratum: Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis (Gastroenterology (1996) 110 (1020- 1027))
H. F. A. Vasen,J. T. Wijnen,Fred H. Menko,Jan H. Kleibeuker,B. G. Taal,G. Griffoen,Fokko M. Nagengast,E. H. Meijers-Heijboer,Lucio Bertario,L. Varesco,L. Bisgaard,J. Mohr,Riccardo Fodde,P M Khan +13 more