J
J. Thomas Parsons
Researcher at University of Virginia
Publications - 94
Citations - 21830
J. Thomas Parsons is an academic researcher from University of Virginia. The author has contributed to research in topics: Focal adhesion & PTK2. The author has an hindex of 55, co-authored 94 publications receiving 20601 citations. Previous affiliations of J. Thomas Parsons include University of Virginia Health System.
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Journal ArticleDOI
Cell migration: integrating signals from front to back.
Anne J. Ridley,Martin A. Schwartz,Keith Burridge,Richard A. Firtel,Mark H. Ginsberg,Gary G. Borisy,J. Thomas Parsons,Alan Rick Horwitz +7 more
TL;DR: The mechanisms underlying the major steps of migration and the signaling pathways that regulate them are described, and recent advances investigating the nature of polarity in migrating cells and the pathways that establish it are outlined.
Journal ArticleDOI
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
TL;DR: Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics.
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Focal adhesion kinase: the first ten years
TL;DR: The protein tyrosine kinase focal adhesion kinase (FAK) plays a prominent role in integrin signaling and results in recruitment of a number of SH2-domain- and SH3- domain-containing proteins, which mediate signaling to several downstream pathways.
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FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly.
Donna J. Webb,Karen Donais,Leanna Whitmore,Sheila M. Thomas,Christopher E. Turner,J. Thomas Parsons,Alan F. Horwitz +6 more
TL;DR: Using quantitative assays, it is shown that kinases and adaptor molecules, including focal adhesion kinase, Src, p130CAS, paxillin, extracellular signal-regulated kinase and myosin light-chain kinase are critical for adhesion turnover at the cell front, a process central to migration.
Journal ArticleDOI
Src family kinases, key regulators of signal transduction
TL;DR: This volume has attempted to provide the reader with an overview of the current understanding of the function of Src family kinases in the regulation of selected cellular signaling pathways.