J
Jack A. Roth
Researcher at University of Texas MD Anderson Cancer Center
Publications - 790
Citations - 55408
Jack A. Roth is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 110, co-authored 764 publications receiving 51306 citations. Previous affiliations of Jack A. Roth include University of Texas System & University of Texas at Austin.
Papers
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Journal ArticleDOI
p53 Gene Replacement for Cancer&Interactions with DNA Damaging Agents
Jack A. Roth,Susan F. Grammer,Stephen G. Swisher,Ritsuko Komaki,John Nemunaitis,James A. Merritt,Raymond E. Meyn +6 more
TL;DR: Conventional therapies may provide renewed potential when used in conjunction with transfer of a functional p53 gene, based on the preclinical and clinical studies discussed.
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Management of intrathoracic leaks following esophagectomy.
TL;DR: Mortality from esophageal anastomotic leaks has declined dramatically in contemporary practice, which seems to be caused by a management strategy that includes observation ofcontained, asymptomatic leaks, operation on uncontained leaks using muscle flaps to reinforce the leak repair, and percutaneous drainage of contained, symptomatic leaks.
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Progression after Chemotherapy Is a Novel Predictor of Poor Outcomes after Pulmonary Metastasectomy in Sarcoma Patients
Elizabeth H. Stephens,Shanda H. Blackmon,Shanda H. Blackmon,Arlene M. Correa,Jack A. Roth,David C. Rice,Wayne L. Hofstetter,Robert S. Benjamin,Reza J. Mehran,Stephen G. Swisher,Garrett L. Walsh,Ara A. Vaporciyan +11 more
TL;DR: Progression of pulmonary metastases after chemotherapy is a novel prognostic factor for survival in patients with sarcoma undergoing metastasectomy, even when controlled for known factors such as disease-free interval and number of metastases.
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Induction of p53-regulated genes in lung cancer cells: implications of the mechanism for adenoviral p53-mediated apoptosis
TL;DR: The data suggest that Ad-p53 induces the expression of a variety of proapoptotic genes and that lack of induction in one of these genes does not block Ad/p53-mediated cell killing in human lung cancer cells.
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The Influence of Reconstructive Technique on Perioperative Pulmonary and Infectious Outcomes Following Chest Wall Resection.
Jonathan Spicer,Jitesh B. Shewale,Mara B. Antonoff,Arlene M. Correa,Wayne B. Hofstetter,David C. Rice,Ara A. Vaporciyan,Reza J. Mehran,Garrett L. Walsh,Jack A. Roth,Stephen G. Swisher,Boris Sepesi +11 more
TL;DR: The type of reconstructive material, whether with rigid, flexible, permanent, or biologic characteristics, does not appear to influence perioperative pulmonary or infectious wound complications.