J
Jian Gu
Researcher at University of Texas MD Anderson Cancer Center
Publications - 285
Citations - 13941
Jian Gu is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Biology. The author has an hindex of 61, co-authored 213 publications receiving 12614 citations. Previous affiliations of Jian Gu include University of Texas at Austin & Baylor College of Medicine.
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Journal ArticleDOI
Erratum: Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer (Nature Genetics (2009) 41 (991-995))
Xifeng Wu,Yuanqing Ye,Lambertus A. Kiemeney,Patrick Sulem,Thorunn Rafnar,Giuseppe Matullo,Daniela Seminara,Teruhiko Yoshida,Norihisa Saeki,Angeline S. Andrew,Colin P.N. Dinney,Bogdan Czerniak,Zuo-Feng Zhang,Anne E. Kiltie,D. Timothy Bishop,Paolo Vineis,Stefano Porru,Frank Buntinx,Eliane Kellen,Maurice P. Zeegers,Rajesh Kumar,Peter Rudnai,Eugene Gurzau,Kvetoslava Koppova,Jose I. Mayordomo,Manuel Sanchez,Berta Saez,Annika Lindblom,Petra J. de Verdier,Gunnar Steineck,Gordon B. Mills,Alan R. Schned,Shen Chih Chang,Jie Lin,David W. Chang,Katherine S. Hale,Tadeusz Majewski,H. Barton Grossman,Steinunn Thorlacius,Unnur Thorsteinsdottir,Katja K.H. Aben,J. Alfred Witjes,Kari Stefansson,Christopher I. Amos,Margaret R. Karagas,Jian Gu +45 more
TL;DR: In the version of this article initially published online, Simonetta Guarrera and Silvia Polidoro were inadvertently omitted from the author list, and an affiliation was omitted for Paolo Vineis as mentioned in this paper.
Journal ArticleDOI
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
Christopher I. Amos,Xifeng Wu,Peter Broderick,Ivan P. Gorlov,Jian Gu,Timothy Eisen,Qiong Dong,Qing Zhang,Xiangjun Gu,Jayaram Vijayakrishnan,Kate Sullivan,Athena Matakidou,Yufei Wang,Gordon B. Mills,Kimberly F. Doheny,Ya Yu Tsai,Wei Vivien Chen,Sanjay Shete,Margaret R. Spitz,Richard S. Houlston +19 more
TL;DR: Two SNPs, rs1051730 and rs8034191, mapping to a region of strong linkage disequilibrium within 15q25.1 containing PSMA4 and the nicotinic acetylcholine receptor subunit genes CHRNA3 and CHRNA5, were significantly associated with risk in both replication sets.
Journal ArticleDOI
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
Yufei Wang,James McKay,Thorunn Rafnar,Zhaoming Wang,Maria Timofeeva,Peter Broderick,Xuchen Zong,Marina Laplana,Yongyue Wei,Younghun Han,Amy Lloyd,Manon Delahaye-Sourdeix,Daniel Chubb,Valerie Gaborieau,William Wheeler,Nilanjan Chatterjee,Gudmar Thorleifsson,Patrick Sulem,Geoffrey Liu,Rudolf Kaaks,Marc Henrion,Ben Kinnersley,Maxime Vallée,Florence LeCalvez-Kelm,Victoria L. Stevens,Susan M. Gapstur,Wei V. Chen,David Zaridze,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Hans E. Krokan,Maiken Elvestad Gabrielsen,Frank Skorpen,Lars J. Vatten,Inger Njølstad,Chu Chen,Gary E. Goodman,Simone Benhamou,Tõnu Vooder,Kristjan Välk,Mari Nelis,Andres Metspalu,Marcin Lener,Jan Lubinski,Mattias Johansson,Paolo Vineis,Antonio Agudo,Françoise Clavel-Chapelon,H. Bas Bueno-de-Mesquita,H. Bas Bueno-de-Mesquita,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Kay-Tee Khaw,Mikael Johansson,Elisabete Weiderpass,Anne Tjønneland,Elio Riboli,Mark Lathrop,Ghislaine Scelo,Demetrius Albanes,Neil E. Caporaso,Yuanqing Ye,Jian Gu,Xifeng Wu,Margaret R. Spitz,Hendrik Dienemann,Albert Rosenberger,Li Su,Athena Matakidou,T. Eisen,Kari Stefansson,Angela Risch,Stephen J. Chanock,David C. Christiani,Rayjean J. Hung,Paul Brennan,Maria Teresa Landi,Richard S. Houlston,Christopher I. Amos +84 more
TL;DR: The analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data and provides further evidence for inherited genetic susceptibility to lung cancer and its biological basis.
Journal ArticleDOI
Bladder Cancer Predisposition: A Multigenic Approach to DNA-Repair and Cell-Cycle–Control Genes
Xifeng Wu,Jian Gu,H. Barton Grossman,Christopher I. Amos,Carol J. Etzel,Maosheng Huang,Qing Zhang,R. E. Millikan,Seth P. Lerner,Colin P.N. Dinney,Margaret R. Spitz +10 more
TL;DR: The data suggest that individuals with a higher number of genetic variations in DNA-repair and cell-cycle-control genes are at an increased risk for bladder cancer, confirming the importance of taking a multigenic pathway-based approach to risk assessment.
Journal ArticleDOI
Mitochondrial DNA Content: Its Genetic Heritability and Association With Renal Cell Carcinoma
Jinliang Xing,Meng Chen,Christopher G. Wood,Jie Lin,Margaret R. Spitz,Jianzhong Ma,Christopher I. Amos,Peter G. Shields,Neal L. Benowitz,Jian Gu,Mariza de Andrade,Gary E. Swan,Xifeng Wu +12 more
TL;DR: In this article, the mtDNA content appears to have high heritability and a statistically significant dose-response relationship was detected between lower mtDNA contents and an increased risk of renal cell carcinoma.