J
Jack Fu
Researcher at Harvard University
Publications - 28
Citations - 945
Jack Fu is an academic researcher from Harvard University. The author has contributed to research in topics: Copy-number variation & Medicine. The author has an hindex of 6, co-authored 17 publications receiving 368 citations. Previous affiliations of Jack Fu include Johns Hopkins University & Broad Institute.
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Journal ArticleDOI
A structural variation reference for medical and population genetics
Ryan L. Collins,Ryan L. Collins,Harrison Brand,Harrison Brand,Konrad J. Karczewski,Konrad J. Karczewski,Xuefang Zhao,Xuefang Zhao,Jessica Alföldi,Jessica Alföldi,Laurent C. Francioli,Laurent C. Francioli,Amit Khera,Amit Khera,Chelsea Lowther,Chelsea Lowther,Laura D. Gauthier,Harold Z. Wang,Harold Z. Wang,Nicholas A. Watts,Nicholas A. Watts,Matthew Solomonson,Matthew Solomonson,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Alexander Baumann,Ruchi Munshi,Mark Walker,Christopher W. Whelan,Yongqing Huang,Ted Brookings,Ted Sharpe,Matthew R. Stone,Matthew R. Stone,Elise Valkanas,Elise Valkanas,Jack Fu,Jack Fu,Grace Tiao,Grace Tiao,Kristen M. Laricchia,Kristen M. Laricchia,Valentin Ruano-Rubio,Christine Stevens,Namrata Gupta,Caroline N. Cusick,Lauren Margolin,Genome Aggregation Database Production Team,Kent D. Taylor,Henry J. Lin,Stephen S. Rich,Wendy S. Post,Yii-Der Ida Chen,Jerome I. Rotter,Chad Nusbaum,Anthony A. Philippakis,Eric S. Lander,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Benjamin M. Neale,Sekar Kathiresan,Mark J. Daly,Eric Banks,Daniel G. MacArthur,Michael E. Talkowski +65 more
TL;DR: A large empirical assessment of sequence-resolved structural variants from 14,891 genomes across diverse global populations in the Genome Aggregation Database (gnomAD) provides a reference map for disease-association studies, population genetics, and diagnostic screening.
Journal ArticleDOI
Rare coding variation provides insight into the genetic architecture and phenotypic context of autism
Jack Fu,F. Kyle Satterstrom,Minshi Peng,Harrison Brand,Ryan L. Collins,Sha-Sha Dong,Brie Wamsley,Lambertus Klei,Lily Wang,Stephanie P Hao,Christine Stevens,Caroline N. Cusick,Mehrtash Babadi,Eric Banks,Brett Collins,Sheila Dodge,Stacey Gabriel,Laura D. Gauthier,Samuel K. Lee,Lindsay Liang,Alicia Ljungdahl,Behrang Mahjani,Laura G. Sloofman,Andrey Smirnov,Mafalda Barbosa,Catalina Betancur,Alfredo Brusco,Brian H.Y. Chung,Edwin H. Cook,Michael L. Cuccaro,Enrico Domenici,Giovanni Battista Ferrero,J. Jay Gargus,Gail E. Herman,Irva Hertz-Picciotto,Patrícia Maciel,Dara S. Manoach,Maria Rita Passos-Bueno,Antonio M. Persico,Alessandra Renieri,James S. Sutcliffe,Flora Tassone,Elisabetta Trabetti,Gabriele Campos,Simona Cardaropoli,Diana Carli,Marcus C. Y. Chan,Chiara Fallerini,Elisa Giorgio,Ana Cristina Girardi,Emily Hansen‐Kiss,So Lun Lee,Carla Lintas,Yunin Ludena,Rachel Nguyen,Lisa Pavinato,Margaret A. Pericak-Vance,Isaac N. Pessah,Rebecca J. Schmidt,Moyra Smith,Claudia Ismania Samogy Costa,Slavica Trajkova,Jaqueline Wang,Mullin H.C. Yu,David M. Cutler,Silvia De Rubeis,Joseph D. Buxbaum,Mark J. Daly,Bernie Devlin,Kathryn Roeder,Stephen Sanders,Michael E. Talkowski +71 more
TL;DR: The authors explored the genes disrupted by these variants from joint analysis of protein-truncating variants (PTVs), missense variants and copy number variants (CNVs) in a cohort of 63,237 individuals.
Posted ContentDOI
A cross-disorder dosage sensitivity map of the human genome
Ryan L. Collins,Ryan L. Collins,Joseph T. Glessner,Joseph T. Glessner,Eleonora Porcu,Eleonora Porcu,Lisa-Marie Niestroj,Jacob C. Ulirsch,Jacob C. Ulirsch,Georgios Kellaris,Georgios Kellaris,Daniel P. Howrigan,Selin Everett,Selin Everett,Kiana Mohajeri,Kiana Mohajeri,Xander Nuttle,Xander Nuttle,Chelsea Lowther,Chelsea Lowther,Jack Fu,Jack Fu,Philip M. Boone,Farid Ullah,Farid Ullah,Kaitlin E. Samocha,Konrad J. Karczewski,Konrad J. Karczewski,Diane Lucente,James F. Gusella,James F. Gusella,Hilary K. Finucane,Hilary K. Finucane,Ludmilla Matyakhina,Swaroop Aradhya,Jeanne Meck,Dennis Lal,Benjamin M. Neale,Jennelle C. Hodge,Alexandre Reymond,Zoltán Kutalik,Zoltán Kutalik,Nicholas Katsanis,Nicholas Katsanis,Erica E. Davis,Erica E. Davis,Hakon Hakonarson,Hakon Hakonarson,Shamil R. Sunyaev,Harrison Brand,Harrison Brand,Michael E. Talkowski +51 more
TL;DR: In this article, the authors meta-analyzed rCNVs from 753,994 individuals across 30 primarily neurological disease phenotypes to create a genome-wide catalog of rCNV association statistics across disorders.
Posted ContentDOI
An open resource of structural variation for medical and population genetics
Ryan L. Collins,Ryan L. Collins,Harrison Brand,Harrison Brand,Konrad J. Karczewski,Konrad J. Karczewski,Xuefang Zhao,Xuefang Zhao,Jessica Alföldi,Jessica Alföldi,Laurent C. Francioli,Laurent C. Francioli,Amit Khera,Amit Khera,Chelsea Lowther,Chelsea Lowther,Laura D. Gauthier,Harold Z. Wang,Harold Z. Wang,Nicholas A. Watts,Nicholas A. Watts,Matthew Solomonson,Matthew Solomonson,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Alexander Baumann,Ruchi Munshi,Mark Walker,Christopher W. Whelan,Christopher W. Whelan,Yongqing Huang,Ted Brookings,Ted Sharpe,Matthew R. Stone,Matthew R. Stone,Elise Valkanas,Elise Valkanas,Jack Fu,Jack Fu,Grace Tiao,Grace Tiao,Kristen M. Laricchia,Kristen M. Laricchia,Ruano-Rubio,Christine Stevens,Namrata Gupta,Lauren Margolin,Kent D. Taylor,Henry J. Lin,Stephen S. Rich,Wendy S. Post,Yii-Der Ida Chen,Jerome I. Rotter,Chad Nusbaum,Anthony A. Philippakis,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Benjamin M. Neale,Sekar Kathiresan,Mark J. Daly,Eric Banks,Daniel G. MacArthur,Michael E. Talkowski +63 more
TL;DR: A reference atlas of SVs from deep whole-genome sequencing of 14,891 individuals across diverse global populations as a component of gnomAD is constructed, finding strong correlations between constraint against predicted loss-of-function (pLoF) SNVs and rare SVs that both disrupt and duplicate protein-coding genes.
Journal ArticleDOI
Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome
Kapil V. Ramachandran,Jack Fu,Thomas B. Schaffer,Chan Hyun Na,Michael Delannoy,Seth S. Margolis +5 more
TL;DR: It is found that the NMP degrades exclusively a large fraction of ribosome-associated nascent polypeptides that are being newly synthesized during neuronal stimulation and proposed that these findings generally define a neuronal activity-induced protein homeostasis program of coordinated protein synthesis and degradation through the N MP.