L
Lauren Margolin
Researcher at Broad Institute
Publications - 13
Citations - 1723
Lauren Margolin is an academic researcher from Broad Institute. The author has contributed to research in topics: Population & Structural variation. The author has an hindex of 9, co-authored 13 publications receiving 1086 citations. Previous affiliations of Lauren Margolin include Massachusetts Institute of Technology.
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Journal ArticleDOI
A structural variation reference for medical and population genetics
Ryan L. Collins,Ryan L. Collins,Harrison Brand,Harrison Brand,Konrad J. Karczewski,Konrad J. Karczewski,Xuefang Zhao,Xuefang Zhao,Jessica Alföldi,Jessica Alföldi,Laurent C. Francioli,Laurent C. Francioli,Amit Khera,Amit Khera,Chelsea Lowther,Chelsea Lowther,Laura D. Gauthier,Harold Z. Wang,Harold Z. Wang,Nicholas A. Watts,Nicholas A. Watts,Matthew Solomonson,Matthew Solomonson,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Alexander Baumann,Ruchi Munshi,Mark Walker,Christopher W. Whelan,Yongqing Huang,Ted Brookings,Ted Sharpe,Matthew R. Stone,Matthew R. Stone,Elise Valkanas,Elise Valkanas,Jack Fu,Jack Fu,Grace Tiao,Grace Tiao,Kristen M. Laricchia,Kristen M. Laricchia,Valentin Ruano-Rubio,Christine Stevens,Namrata Gupta,Caroline N. Cusick,Lauren Margolin,Genome Aggregation Database Production Team,Kent D. Taylor,Henry J. Lin,Stephen S. Rich,Wendy S. Post,Yii-Der Ida Chen,Jerome I. Rotter,Chad Nusbaum,Anthony A. Philippakis,Eric S. Lander,Eric S. Lander,Eric S. Lander,Stacey Gabriel,Benjamin M. Neale,Sekar Kathiresan,Mark J. Daly,Eric Banks,Daniel G. MacArthur,Michael E. Talkowski +65 more
TL;DR: A large empirical assessment of sequence-resolved structural variants from 14,891 genomes across diverse global populations in the Genome Aggregation Database (gnomAD) provides a reference map for disease-association studies, population genetics, and diagnostic screening.
Journal ArticleDOI
Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation
Carolina Roselli,Mark Chaffin,Lu-Chen Weng,Lu-Chen Weng,Stefanie Aeschbacher,Gustav Ahlberg,Christine M. Albert,Peter Almgren,Alvaro Alonso,Christopher D. Anderson,Christopher D. Anderson,Krishna G. Aragam,Krishna G. Aragam,Dan E. Arking,John Barnard,Traci M. Bartz,Emelia J. Benjamin,Emelia J. Benjamin,Nathan A. Bihlmeyer,Joshua C. Bis,Heather L. Bloom,Eric Boerwinkle,Erwin B. Bottinger,Jennifer A. Brody,Hugh Calkins,Archie Campbell,Thomas P. Cappola,John F. Carlquist,John F. Carlquist,Daniel I. Chasman,Daniel I. Chasman,Lin Y. Chen,Yii-Der Ida Chen,Eue Keun Choi,Seung Hoan Choi,Ingrid E. Christophersen,Ingrid E. Christophersen,Ingrid E. Christophersen,Mina K. Chung,John W. Cole,John W. Cole,David Conen,David Conen,James P. Cook,Harry J.G.M. Crijns,Michael J. Cutler,Scott M. Damrauer,Scott M. Damrauer,Brian R. Daniels,Dawood Darbar,Graciela Delgado,Joshua C. Denny,Martin Dichgans,Martin Dichgans,Marcus Dörr,Elton A. M. P. Dudink,Samuel C. Dudley,Nada Esa,Tõnu Esko,Tõnu Esko,Markku Eskola,Diane Fatkin,Diane Fatkin,Diane Fatkin,Stephan B. Felix,Ian Ford,Oscar H. Franco,Bastiaan Geelhoed,Raji P. Grewal,Raji P. Grewal,Vilmundur Gudnason,Xiuqing Guo,Namrata Gupta,Stefan Gustafsson,Rebecca Gutmann,Anders Hamsten,Tamara B. Harris,Caroline Hayward,Susan R. Heckbert,Susan R. Heckbert,Jussi Hernesniemi,Lynne J. Hocking,Albert Hofman,Andrea R. V. R. Horimoto,Jie Huang,Paul L. Huang,Jennifer E. Huffman,Erik Ingelsson,Erik Ingelsson,Esra Gucuk Ipek,Kaoru Ito,Jordi Jimenez-Conde,Jordi Jimenez-Conde,Renee Johnson,J. Wouter Jukema,Stefan Kääb,Mika Kähönen,Yoichiro Kamatani,John P. Kane,Adnan Kastrati,Sekar Kathiresan,Sekar Kathiresan,Petra Katschnig-Winter,Maryam Kavousi,Thorsten Kessler,Bas L.J.H. Kietselaer,Paulus Kirchhof,Marcus E. Kleber,Stacey Knight,Stacey Knight,José Eduardo Krieger,Michiaki Kubo,Lenore J. Launer,Jari Laurikka,Terho Lehtimäki,Kirsten Leineweber,Rozenn N. Lemaitre,Man Li,Man Li,Hong Euy Lim,Henry J. Lin,Honghuang Lin,Honghuang Lin,Lars Lind,Cecilia M. Lindgren,Marja-Liisa Lokki,Barry London,Ruth J. F. Loos,Siew-Kee Low,Yingchang Lu,Leo-Pekka Lyytikäinen,Peter W. Macfarlane,Patrik K. E. Magnusson,Anubha Mahajan,Rainer Malik,Alfredo José Mansur,Gregory M. Marcus,Lauren Margolin,Kenneth B. Margulies,Winfried März,Winfried März,David D. McManus,Olle Melander,Sanghamitra Mohanty,Jay A. Montgomery,Michael Morley,Andrew P. Morris,Martina Müller-Nurasyid,Andrea Natale,Saman Nazarian,Benjamin Neumann,Christopher Newton-Cheh,Christopher Newton-Cheh,Maartje N. Niemeijer,Kjell Nikus,Peter M. Nilsson,Raymond Noordam,Heidi Oellers,Morten S. Olesen,Marju Orho-Melander,Sandosh Padmanabhan,Hui Nam Pak,Guillaume Paré,Guillaume Paré,Nancy L. Pedersen,Joanna Pera,Alexandre C. Pereira,David J. Porteous,Bruce M. Psaty,Bruce M. Psaty,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Clive R. Pullinger,Daniel J. Rader,Lena Refsgaard,Marta Ribasés,Marta Ribasés,Paul M. Ridker,Michiel Rienstra,Lorenz Risch,Dan M. Roden,Jonathan Rosand,Jonathan Rosand,Michael A. Rosenberg,Michael A. Rosenberg,Natalia S. Rost,Natalia S. Rost,Jerome I. Rotter,Samir Saba,Roopinder K. Sandhu,Renate B. Schnabel,Katharina Schramm,Heribert Schunkert,Claudia Schurman,Stuart A. Scott,Ilkka Seppälä,Christian M. Shaffer,Svati H. Shah,Alaa Shalaby,Alaa Shalaby,Jaemin Shim,M. Benjamin Shoemaker,Joylene E. Siland,Juha Sinisalo,Moritz F. Sinner,Agnieszka Slowik,Albert V. Smith,Blair H. Smith,J. Gustav Smith,J. Gustav Smith,Jonathan D. Smith,Nicholas L. Smith,Nicholas L. Smith,Elsayed Z. Soliman,Nona Sotoodehnia,Bruno H. Stricker,Albert Y. Sun,Han Sun,Jesper Hastrup Svendsen,Toshihiro Tanaka,Kahraman Tanriverdi,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Sébastien Thériault,Sébastien Thériault,Stella Trompet,Nathan R. Tucker,Nathan R. Tucker,Arnljot Tveit,Arnljot Tveit,André G. Uitterlinden,Pim van der Harst,Isabelle C. Van Gelder,David R. Van Wagoner,Niek Verweij,Efthymia Vlachopoulou,Uwe Völker,Biqi Wang,Peter Weeke,Peter Weeke,Bob Weijs,Raul Weiss,Stefan Weiss,Quinn S. Wells,Kerri L. Wiggins,Jorge A. Wong,Daniel Woo,Bradford B. Worrall,Pil Sung Yang,Jie Yao,Zachary T. Yoneda,Tanja Zeller,Lingyao Zeng,Steven A. Lubitz,Steven A. Lubitz,Kathryn L. Lunetta,Kathryn L. Lunetta,Patrick T. Ellinor,Patrick T. Ellinor +260 more
TL;DR: This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation that are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.
Journal ArticleDOI
The genomic landscape of balanced cytogenetic abnormalities associated with human congenital anomalies
Claire Redin,Claire Redin,Harrison Brand,Harrison Brand,Ryan L. Collins,Ryan L. Collins,Tammy Kammin,Elyse Mitchell,Jennelle C. Hodge,Jennelle C. Hodge,Jennelle C. Hodge,Carrie Hanscom,Carrie Hanscom,Vamsee Pillalamarri,Vamsee Pillalamarri,Catarina M. Seabra,Catarina M. Seabra,Catarina M. Seabra,Mary-Alice Abbott,Omar A. Abdul-Rahman,Erika Aberg,Rhett Adley,Sofia L. Alcaraz-Estrada,Fowzan S. Alkuraya,Yu An,Yu An,Mary-Anne Anderson,Caroline Antolik,Caroline Antolik,Kwame Anyane-Yeboa,Joan F. Atkin,Joan F. Atkin,Tina M. Bartell,Jonathan A. Bernstein,Elizabeth Beyer,Elizabeth Beyer,Ian Blumenthal,Ernie M.H.F. Bongers,Eva H. Brilstra,Chester W. Brown,Chester W. Brown,Hennie T. Brüggenwirth,Bert Callewaert,Colby Chiang,Ken Corning,Helen Cox,Edwin Cuppen,Benjamin Currall,Tom Cushing,Dezso David,Matthew A. Deardorff,Annelies Dheedene,Marc D'Hooghe,Bert B.A. de Vries,Dawn L. Earl,Heather L. Ferguson,Heather Fisher,David R. FitzPatrick,Pamela Gerrol,Daniela Giachino,Joseph T. Glessner,Joseph T. Glessner,Troy J. Gliem,Margo Grady,Brett H. Graham,Cristin Griffis,Cristin Griffis,Karen W. Gripp,Andrea L. Gropman,Andrea Hanson-Kahn,David J. Harris,Mark A. Hayden,Rosamund Hill,Ron Hochstenbach,Jodi D. Hoffman,Robert J. Hopkin,Robert J. Hopkin,Monika Weisz Hubshman,Monika Weisz Hubshman,A. Micheil Innes,Mira Irons,Melita Irving,Jessie C. Jacobsen,Sandra Janssens,Tamison Jewett,John P. Johnson,Marjolijn C.J. Jongmans,Stephen G. Kahler,David A. Koolen,Jerome Korzelius,Peter M. Kroisel,Yves Lacassie,William Lawless,Emmanuelle Lemyre,Kathleen A. Leppig,Kathleen A. Leppig,Alex V. Levin,Haibo Li,Hong Li,Eric C. Liao,Cynthia Lim,Edward J. Lose,Diane Lucente,Michael J. Macera,Poornima Manavalan,Giorgia Mandrile,Carlo Marcelis,Lauren Margolin,Tamara Mason,Diane Masser-Frye,Michael W. McClellan,Cinthya J Zepeda Mendoza,Björn Menten,Sjors Middelkamp,Liya R Mikami,Emily Moe,Emily Moe,Shehla Mohammed,Tarja Mononen,Megan Mortenson,Megan Mortenson,Graciela Moya,Aggie W. M. Nieuwint,Zehra Ordulu,Sandhya Parkash,Sandhya Parkash,Susan P. Pauker,Shahrin Pereira,Danielle Perrin,Katy Phelan,Raul Eduardo Pina Aguilar,Pino J. Poddighe,Giulia Pregno,Salmo Raskin,Linda M. Reis,Linda M. Reis,William J. Rhead,William J. Rhead,Debra Rita,Ivo Renkens,Filip Roelens,Jayla Ruliera,Patrick Rump,Samantha L.P. Schilit,Ranad Shaheen,Rebecca Sparkes,Erica Spiegel,Blair Stevens,Matthew R. Stone,Matthew R. Stone,Julia Tagoe,Joseph V. Thakuria,Bregje W.M. van Bon,Jiddeke M. van de Kamp,Ineke van der Burgt,Ton van Essen,Conny M. A. van Ravenswaaij-Arts,Markus J. van Roosmalen,Sarah Vergult,Catharina M L Volker-Touw,Dorothy Warburton,Matthew J. Waterman,Matthew J. Waterman,Susan Wiley,Anna Wilson,Maria de la Concepcion A Yerena-de Vega,Roberto T. Zori,Brynn Levy,Han G. Brunner,Han G. Brunner,Nicole de Leeuw,Wigard P. Kloosterman,Erik C. Thorland,Cynthia C. Morton,Cynthia C. Morton,Cynthia C. Morton,James F. Gusella,James F. Gusella,Michael E. Talkowski,Michael E. Talkowski +179 more
TL;DR: It is proposed that sequence-level resolution dramatically improves prediction of clinical outcomes for balanced rearrangements and provides insight into new pathogenic mechanisms, such as altered regulation due to changes in chromosome topology.
Journal ArticleDOI
Defining the diverse spectrum of inversions, complex structural variation, and chromothripsis in the morbid human genome.
Ryan L. Collins,Ryan L. Collins,Harrison Brand,Harrison Brand,Claire Redin,Claire Redin,Carrie Hanscom,Carrie Hanscom,Caroline Antolik,Caroline Antolik,Matthew R. Stone,Matthew R. Stone,Joseph T. Glessner,Joseph T. Glessner,Tamara Mason,Giulia Pregno,Naghmeh Dorrani,Giorgia Mandrile,Daniela Giachino,Danielle Perrin,Cole Walsh,Michelle Cipicchio,Maura Costello,Alexei Stortchevoi,Alexei Stortchevoi,Joon Yong An,Benjamin Currall,Benjamin Currall,Catarina M. Seabra,Catarina M. Seabra,Catarina M. Seabra,Ashok Ragavendran,Ashok Ragavendran,Lauren Margolin,Julian A. Martinez-Agosto,Diane Lucente,Brynn Levy,Stephen Sanders,Ronald J. Wapner,Fabiola Quintero-Rivera,Wigard P. Kloosterman,Michael E. Talkowski,Michael E. Talkowski +42 more
TL;DR: A genome-wide map of large SV is constructed and 16 recurrent subclasses of complex SV (cxSV) are characterized, revealing that cxSV are larger and rarer than canonical SV and should be considered in genomic studies of human disease.
Journal ArticleDOI
Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.
Seung Hoan Choi,Lu-Chen Weng,Lu-Chen Weng,Carolina Roselli,Honghuang Lin,Christopher M. Haggerty,M. Benjamin Shoemaker,John Barnard,Dan E. Arking,Daniel I. Chasman,Daniel I. Chasman,Christine M. Albert,Mark Chaffin,Nathan R. Tucker,Nathan R. Tucker,Jonathan D. Smith,Namrata Gupta,Stacey Gabriel,Lauren Margolin,Marisa A. Shea,Christian M. Shaffer,Zachary T. Yoneda,Eric Boerwinkle,Nicholas L. Smith,Edwin K. Silverman,Susan Redline,Ramachandran S. Vasan,Esteban G. Burchard,Stephanie M. Gogarten,Cecelia A. Laurie,Thomas W. Blackwell,Gonçalo R. Abecasis,David J. Carey,Brandon K. Fornwalt,Diane T. Smelser,Aris Baras,Frederick E. Dewey,Cashell E. Jaquish,George J. Papanicolaou,Nona Sotoodehnia,David R. Van Wagoner,Bruce M. Psaty,Sekar Kathiresan,Dawood Darbar,Alvaro Alonso,Susan R. Heckbert,Susan R. Heckbert,Mina K. Chung,Dan M. Roden,Emelia J. Benjamin,Michael F. Murray,Kathryn L. Lunetta,Steven A. Lubitz,Steven A. Lubitz,Patrick T. Ellinor,Patrick T. Ellinor +55 more
TL;DR: In a case-control study, there was a statistically significant association between an LOF variant in the TTN gene and early-onset AF, with the variant present in a small percentage of participants with early-ONSet AF (the case group).