J
Jacky Man Chun Chan
Researcher at Hospital Authority
Publications - 10
Citations - 1729
Jacky Man Chun Chan is an academic researcher from Hospital Authority. The author has contributed to research in topics: Coronavirus & Antigen. The author has an hindex of 8, co-authored 10 publications receiving 1090 citations.
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Journal ArticleDOI
Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans.
Prabhu S. Arunachalam,Florian Wimmers,Chris Ka Pun Mok,Ranawaka A.P.M. Perera,Madeleine K D Scott,Thomas Hagan,Natalia Sigal,Yupeng Feng,Laurel Bristow,Owen Tak-Yin Tsang,Dhananjay Wagh,John A. Coller,Kathryn L. Pellegrini,Dmitri Kazmin,Ghina Alaaeddine,Wai Shing Leung,Jacky Man Chun Chan,Thomas Shiu Hong Chik,Chris Yau Chung Choi,Christopher Huerta,Michele Paine McCullough,Huibin Lv,Evan J. Anderson,Srilatha Edupuganti,Amit A. Upadhyay,Steve E. Bosinger,Steve E. Bosinger,Holden T. Maecker,Purvesh Khatri,Nadine Rouphael,Malik Peiris,Bali Pulendran +31 more
TL;DR: In the peripheral blood mononuclear cells of COVID-19 patients, the authors observed reduced expression of human leukocyte antigen class DR (HLA-DR) and proinflammatory cytokines by myeloid cells as well as impaired mammalian target of rapamycin (mTOR) signaling and interferon-α (IFN-α) production by plasmacytoid dendritic cells.
Journal ArticleDOI
Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections.
Huibin Lv,Nicholas C. Wu,Owen Tak-Yin Tsang,Meng Yuan,Ranawaka A.P.M. Perera,Wai Shing Leung,Ray T.Y. So,Jacky Man Chun Chan,Garrick K. Yip,Thomas Shiu Hong Chik,Yiquan Wang,Chris Yau Chung Choi,Yihan Lin,Wilson W. Ng,Jincun Zhao,Leo L.M. Poon,J S Malik Peiris,Ian A. Wilson,Chris Ka Pun Mok +18 more
TL;DR: Analysis of plasma from patients infected by SARS-CoV-2 or SARV, and from infected or immunized mice shows cross-reactivity in antibody binding to the spike protein is common, but cross-neutralization of the live viruses may be rare, indicating the presence of non-neutralizing antibody response to conserved epitopes in the spike.
Journal ArticleDOI
Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020.
Ranawaka A.P.M. Perera,Chris Ka Pun Mok,Owen Tak-Yin Tsang,Huibin Lv,Ronald L.W. Ko,Nicholas C. Wu,Meng Yuan,Wai Shing Leung,Jacky Man Chun Chan,Thomas Shiu Hong Chik,Chris Yau Chung Choi,Kathy Leung,Kin Ho Chan,Karl C. K. Chan,Ka Chi Li,Joseph T. Wu,Ian A. Wilson,Arnold S. Monto,Leo L.M. Poon,Malik Peiris +19 more
TL;DR: Using IgG ELISA based on the RBD of the spike protein to screen sera for SARS-CoV-2 antibody, followed by confirmation using PRNT90, is a valid approach for large-scale sero-epidemiology studies.
Posted ContentDOI
Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections.
Huibin Lv,Nicholas C. Wu,Owen Tak-Yin Tsang,Meng Yuan,Ranawaka A.P.M. Perera,Wai Shing Leung,Ray T.Y. So,Jacky Man Chun Chan,Garrick K. Yip,Thomas Shiu Hong Chik,Yiquan Wang,Chris Yau Chung Choi,Yihan Lin,Wilson W. Ng,Jincun Zhao,Leo L.M. Poon,J S Malik Peiris,Ian A. Wilson,Chris Ka Pun Mok +18 more
TL;DR: The results show that while cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses is rare, indicating the presence of non-neutralizing antibody response to conserved epitopes in the spike.
Journal ArticleDOI
Chronic hepatitis C genotype 6 responds better to pegylated interferon and ribavirin combination therapy than genotype 1.
Owen Tak-Yin Tsang,Jonpaul S.T Zee,Jacky Man Chun Chan,Reggie S.T Li,Yee-Man Kan,Francis T.W Li,Fu-Hang Lo,David Alan Chow,Kent W.L Cheung,K H Chan,Yat-Wah Yeung,Fook-Hong Ng,Michael K. K. Li,Wai-Keung Kwan,Thomas Sik-To Lai +14 more
TL;DR: A retrospective study to compare the therapeutic responses of this regimen in patients infected with genotype 6 and genotype 1 and to evaluate the effectiveness of pegylated interferon and ribavirin treatment.