Kathryn L. Pellegrini

TL;DR: In the peripheral blood mononuclear cells of COVID-19 patients, the authors observed reduced expression of human leukocyte antigen class DR (HLA-DR) and proinflammatory cytokines by myeloid cells as well as impaired mammalian target of rapamycin (mTOR) signaling and interferon-α (IFN-α) production by plasmacytoid dendritic cells.

TL;DR: In this article, the authors used a system vaccinology approach to comprehensively profile the innate and adaptive immune responses of 56 healthy volunteers who were vaccinated with the Pfizer-BioNTech mRNA vaccine (BNT162b2).

TL;DR: This study demonstrates endothelial disruption and vascular thrombosis in histopathologic sections of lungs from both humans and rhesus macaques infected with SARS-CoV-2 and suggests potential therapeutic targets for COVID-19.

TL;DR: A beneficial role for, and elucidate the immunological mechanisms underlying, the use of baricitinib as a frontline treatment for inflammation induced by SARS-CoV-2 infection are elucidated.

TL;DR: In this article, modified vaccinia Ankara (MVA) vectors expressing membrane-anchored pre-fusion stabilized spike (mVA/S) but not secreted S1 induced strong neutralizing antibody responses against SARS-CoV-2 in mice.