R
Ray T.Y. So
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 25
Citations - 2421
Ray T.Y. So is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Epitope & Coronavirus. The author has an hindex of 9, co-authored 19 publications receiving 1686 citations. Previous affiliations of Ray T.Y. So include University of Hong Kong.
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Journal ArticleDOI
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV.
Meng Yuan,Nicholas C. Wu,Xueyong Zhu,Chang-Chun D Lee,Ray T.Y. So,Huibin Lv,Chris Ka Pun Mok,Ian A. Wilson +7 more
TL;DR: The crystal structure of CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient, in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein at 3.1-angstrom resolution is determined, providing molecular insights into antibody recognition of Sars-Cov-2.
Journal ArticleDOI
Cross-reactive Antibody Response between SARS-CoV-2 and SARS-CoV Infections.
Huibin Lv,Nicholas C. Wu,Owen Tak-Yin Tsang,Meng Yuan,Ranawaka A.P.M. Perera,Wai Shing Leung,Ray T.Y. So,Jacky Man Chun Chan,Garrick K. Yip,Thomas Shiu Hong Chik,Yiquan Wang,Chris Yau Chung Choi,Yihan Lin,Wilson W. Ng,Jincun Zhao,Leo L.M. Poon,J S Malik Peiris,Ian A. Wilson,Chris Ka Pun Mok +18 more
TL;DR: Analysis of plasma from patients infected by SARS-CoV-2 or SARV, and from infected or immunized mice shows cross-reactivity in antibody binding to the spike protein is common, but cross-neutralization of the live viruses may be rare, indicating the presence of non-neutralizing antibody response to conserved epitopes in the spike.
Posted ContentDOI
A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV
Meng Yuan,Nicholas C. Wu,Xueyong Zhu,Chang-Chun D Lee,Ray T.Y. So,Huibin Lv,Chris Ka Pun Mok,Ian A. Wilson +7 more
TL;DR: The crystal structure of the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein in complex with CR3022, a neutralizing antibody previously isolated from a convalescent SARS patient is determined.
Journal ArticleDOI
MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity
Daniel K.W. Chu,Kenrie P Y Hui,Ranawaka A.P.M. Perera,Eve Miguel,Daniela Niemeyer,Jincun Zhao,Jincun Zhao,Rudragouda Channappanavar,Gytis Dudas,Jamiu O Oladipo,Jamiu O Oladipo,Amadou Traoré,Ouafaa Fassi-Fihri,Abraham Ali,Getnet Fekadu Demissie,Doreen Muth,Michael C. W. Chan,John M. Nicholls,David K. Meyerholz,S A Kuranga,Gezahegne Mamo,Ziqi Zhou,Ray T.Y. So,Maged Gomaa Hemida,Maged Gomaa Hemida,Richard J. Webby,François Roger,François Roger,Andrew Rambaut,Andrew Rambaut,Leo L.M. Poon,Stanley Perlman,Christian Drosten,Véronique Chevalier,Véronique Chevalier,Malik Peiris +35 more
TL;DR: Viral genetic and phenotypic differences in viruses from West Africa may be relevant to differences in zoonotic potential, highlighting the need for studies of MERS-CoV at the animal–human interface.
Posted ContentDOI
Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections.
Huibin Lv,Nicholas C. Wu,Owen Tak-Yin Tsang,Meng Yuan,Ranawaka A.P.M. Perera,Wai Shing Leung,Ray T.Y. So,Jacky Man Chun Chan,Garrick K. Yip,Thomas Shiu Hong Chik,Yiquan Wang,Chris Yau Chung Choi,Yihan Lin,Wilson W. Ng,Jincun Zhao,Leo L.M. Poon,J S Malik Peiris,Ian A. Wilson,Chris Ka Pun Mok +18 more
TL;DR: The results show that while cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses is rare, indicating the presence of non-neutralizing antibody response to conserved epitopes in the spike.