H
Huy-Dung Hoang
Researcher at Children's Hospital of Eastern Ontario
Publications - 21
Citations - 754
Huy-Dung Hoang is an academic researcher from Children's Hospital of Eastern Ontario. The author has contributed to research in topics: Oncolytic virus & Translation (biology). The author has an hindex of 11, co-authored 17 publications receiving 428 citations. Previous affiliations of Huy-Dung Hoang include University of Ottawa.
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Journal ArticleDOI
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
David Olagnier,Ensieh Farahani,Jacob Thyrsted,Julia Blay-Cadanet,Angela Herengt,Manja Idorn,Alon Schneider Hait,Alon Schneider Hait,Bruno Hernáez,Alice Knudsen,Marie B. Iversen,Mirjam Schilling,Sofie E. Jørgensen,Sofie E. Jørgensen,Michelle M. Thomsen,Michelle M. Thomsen,Line S. Reinert,Michael Lappe,Huy-Dung Hoang,Victoria H. Gilchrist,Anne Louise Hansen,Rasmus Ottosen,Camilla G. Nielsen,Charlotte Möller,Demi van der Horst,Suraj Peri,Siddharth Balachandran,Jinrong Huang,Martin R. Jakobsen,Esben B. Svenningsen,Thomas B. Poulsen,Lydia Bartsch,Anne L. Thielke,Yonglun Luo,Tommy Alain,Jan Rehwinkel,Antonio Alcami,John Hiscott,Trine H. Mogensen,Trine H. Mogensen,Søren R. Paludan,Christian K. Holm +41 more
TL;DR: NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2.
Journal ArticleDOI
La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1)
Bruno D. Fonseca,Chadi Zakaria,Jian Jun Jia,Tyson E. Graber,Yuri V. Svitkin,Soroush Tahmasebi,Danielle Healy,Huy-Dung Hoang,Jacob Malte Jensen,Ilo T. Diao,Alexandre A. Lussier,Christopher Dajadian,Niranjan Padmanabhan,Walter Wang,Edna Matta-Camacho,Jaclyn Hearnden,Ewan M. Smith,Yoshinori Tsukumo,Akiko Yanagiya,Masahiro Morita,Emmanuel Petroulakis,Jose L. González,Greco Hernández,Tommy Alain,Christian Kroun Damgaard +24 more
TL;DR: It is reported that LARP1 functions as a key repressor of TOP mRNA translation downstream of mTORC1, and reducing LARP 1 protein levels by RNA interference attenuates the inhibitory effect of rapamycin, Torin 1, and amino acid deprivation on TOP mRNAtranslation.
Journal ArticleDOI
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.
Fuan Wang,Tommy Alain,Kristy J. Szretter,Kyle B Stephenson,Jonathan Pol,Matthew J. Atherton,Huy-Dung Hoang,Bruno D. Fonseca,Chadi Zakaria,Lan Chen,Zainab Rangwala,Adam Hesch,Eva Sin Yan Chan,Carly Tuinman,Mehul S. Suthar,Zhaozhao Jiang,Ali A. Ashkar,George Thomas,George Thomas,Sara C. Kozma,Michael Gale,Katherine A. Fitzgerald,Michael S. Diamond,Karen L. Mossman,Nahum Sonenberg,Yonghong Wan,Brian D. Lichty +26 more
TL;DR: It is demonstrated that infection with DNA viruses induced interaction of the metabolic checkpoint kinase mTOR downstream effector and kinase S6K1 and the signaling adaptor STING in a manner dependent on the DNA sensor cGAS.
Journal ArticleDOI
mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1.
Jian-Jun Jia,Roni M. Lahr,Michael T Solgaard,Bruno J Moraes,Roberta Pointet,An-Dao Yang,Giovanna Celucci,Tyson E. Graber,Huy-Dung Hoang,Marius R. Niklaus,Izabella A. Pena,Anne Kruse Hollensen,Ewan M. Smith,Malik Chaker-Margot,Leonie Anton,Christopher Dajadian,Mark Livingstone,Jaclyn Hearnden,Xu-Dong Wang,Yonghao Yu,Timm Maier,Christian Kroun Damgaard,Andrea J. Berman,Tommy Alain,Bruno D. Fonseca +24 more
TL;DR: In this article, the authors reveal that mTORC1 phosphorylates LARP1 in vitro and in vivo, activities that are efficiently inhibited by rapamycin and torin1.
Journal ArticleDOI
Near real-time determination of B.1.1.7 in proportion to total SARS-CoV-2 viral load in wastewater using an allele-specific primer extension PCR strategy.
Tyson E. Graber,Elisabeth Mercier,Kamya Bhatnagar,Meghan L.M. Fuzzen,Patrick M. D'Aoust,Huy-Dung Hoang,Xin Tian,Syeda Tasneem Towhid,Julio Plaza-Díaz,Walaa Eid,Tommy Alain,Ainslie Butler,Lawrence Goodridge,Mark R. Servos,Robert Delatolla +14 more
TL;DR: In this article, the authors describe and validate a primer extension PCR strategy targeting a signature mutation in the N gene of SARS-CoV-2, which can provide public health units with an additional and much needed tool to rapidly triangulate VOC incidence/prevalence with high sensitivity and lineage specificity.