J
Jacob Beal
Researcher at BBN Technologies
Publications - 221
Citations - 5069
Jacob Beal is an academic researcher from BBN Technologies. The author has contributed to research in topics: Synthetic biology & Operational semantics. The author has an hindex of 33, co-authored 218 publications receiving 4282 citations. Previous affiliations of Jacob Beal include Massachusetts Institute of Technology & Raytheon.
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Journal ArticleDOI
Cas9 gRNA engineering for genome editing, activation and repression
Samira Kiani,Alejandro Chavez,Alejandro Chavez,Marcelle Tuttle,Richard N. Hall,Raj Chari,Dmitry Ter-Ovanesyan,Dmitry Ter-Ovanesyan,Jason Qian,Jason Qian,Benjamin W. Pruitt,Jacob Beal,Suhani Vora,Suhani Vora,Suhani Vora,Joanna Buchthal,Emma J. K. Kowal,Mohammad R. Ebrahimkhani,James J. Collins,Ron Weiss,George M. Church,George M. Church +21 more
TL;DR: In this paper, the length of Cas9-associated guide RNA (gRNA) was altered to control Cas9 nuclease activity and simultaneously perform genome editing and transcriptional regulation with a single Cas9 protein.
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The Synthetic Biology Open Language (SBOL) provides a community standard for communicating designs in synthetic biology
Michal Galdzicki,Kevin Clancy,Ernst Oberortner,Matthew Pocock,Jacqueline Quinn,Cesar Rodriguez,Nicholas Roehner,Mandy L. Wilson,Laura Adam,J. Christopher Anderson,Bryan Bartley,Jacob Beal,Deepak Chandran,Joanna Chen,Douglas Densmore,Drew Endy,Raik Grünberg,Jennifer Hallinan,Nathan J. Hillson,Jeffrey Johnson,Allan Kuchinsky,Matthew W. Lux,Goksel Misirli,Jean Peccoud,Hector Plahar,Evren Sirin,Guy-Bart Stan,Alan Villalobos,Anil Wipat,John H. Gennari,Chris J. Myers,Herbert M. Sauro +31 more
TL;DR: The Synthetic Biology Open Language (SBOL) is described, a proposed data standard for exchanging designs within the synthetic biology community that represents synthetic biology designs in a community-driven, formalized format for exchange between software tools, research groups and commercial service providers.
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CRISPR transcriptional repression devices and layered circuits in mammalian cells
Samira Kiani,Jacob Beal,Mohammad R. Ebrahimkhani,Jin Huh,Richard N. Hall,Zhen Xie,Yinqing Li,Ron Weiss +7 more
TL;DR: In this paper, a modular transcriptional repression architecture based on clustered regularly interspaced palindromic repeats (CRISPR) system was presented for regulated expression of guide RNAs in human cells.
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Infrastructure for engineered emergence on sensor/actuator networks
Jacob Beal,Jonathan Bachrach +1 more
TL;DR: This work has begun the process of transforming the science into an engineering discipline in the domain of sensor/actuator network applications, observing that in many applications the deployed network approximates a physical space and that the space, rather than the network, is being programmed.
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Aggregate Programming for the Internet of Things
TL;DR: Through field calculus constructs and building-block APIs, aggregate programming could help unlock the IoT's true potential by allowing complex distributed Services to be specified succinctly and by enabling such services to be safely encapsulated, modulated, and composed with one another.