Jacob G. Bundy

TL;DR: Transcriptomic and metabolomic data are used to show that a change in geometry can explain a variety of phenomena during growth, including changes in the relative expression levels of cytoplasmic and membrane proteins and changes in metabolite pools of free amino acids.

TL;DR: A hypothesis is proposed whereby the positive clinical effects of HS treatment are explained by the osmotic sensitivity of the mucoid sub-population of P. aeruginosa in the CF lung leading to selection against this group in favor of the Osmotically resistant non-mucoid variants.

TL;DR: Untargeted NMR metabolic profiling (metabolomics) of a number of different recombinant strains is used, carried out in a miniaturized format suitable for screening-level experiments, and identified anumber of metabolites which correlated well with UPR-relevant gene transcripts, and so could be potential biomarkers for future high-throughput screening of large numbers of P. pastoris clones.

TL;DR: Time-resolved metabolic footprinting (TReF) is described, a technique which employs nuclear magnetic resonance spectroscopy and nonlinear curve fitting to understand and visualize metabolite utilization of P. aeruginosa.

TL;DR: Tissue arsenic concentrations varied between lineages, supporting previous observations that there are differences in the way the two lineages have adapted to manage exposure to this metalloid.