Jacob G. Bundy

TL;DR: Current knowledge of pathophysiological mechanisms underlying P. aeruginosa infection in CF is summarized, established treatments are discussed, and an overview is offered of novel detection methods and therapeutic strategies in development.

TL;DR: This study acts as a proof of principle for the use of NMR-based metabolic profiling as a diagnostic tool for ecotoxicological research in polluted field soils.

TL;DR: There was some evidence that bioremediated soils were returning to control values by the end of the experiment, supported by the bioassay results which showed an initial increase in toxicity as a result of the oil addition which had then decreased by the conclusion of the Experiment.

TL;DR: A novel mechanism for the growth, and possibly even the formation, of sub-RPE deposits is proposed, namely, that the deposit growth and formation begin with the deposition of insoluble HAP shells around naturally occurring, cholesterol-containing extracellular lipid droplets at the RPE/choroid interface; proteins and lipids then attach to these shells, initiating or supporting the growth ofSub-R PE deposits.

TL;DR: A primary response to low levels of cadmium is the differential regulation of the C. elegans trans-sulfuration pathway, which channels the flux from methionine through cysteine into phytochelatin synthesis, which is backed up by the finding that phytOChelatin synthase mutants (pcs-1) were at least an order of magnitude more sensitive to Cadmium than single or double metallothionein mutants.