Jacob G. Bundy

TL;DR: Investigating the acid, base and metal ion dependent 1H NMR chemical shift variations and limits of the main metabolites in a complex biological mixture and measuring the peak variations induced by the main metal ions present in urine found these data to be a valuable resource for metabolite profiling experiments and for the development of automated metabolite alignment and identification algorithms.

TL;DR: This work developed a protocol for efficient tissue disruption and metabolite extraction of the earthworm Lumbricus rubellus guided by prior biological knowledge as well as metrics based on the data, and evaluated different approaches such as heating and filtration to counteract this.

TL;DR: Phytochelatins are small cysteine-rich non-ribosomal peptides that chelate soft metal and metalloid ions, such as cadmium and arsenic, and there was no evidence of biological transformation of arsenic as a result of laboratory arsenic exposure.

TL;DR: The results indicate that microRNA knock-down is a useful tool to manipulate anaerobic metabolism in C. reinhardtii and the production of 3-hydroxybutyrate was identified in knockdown line cultures during the transition between microaerobic and anoxic conditions.

TL;DR: Data show that NMR-based metabolite profiling has sufficient sensitivity to identify the metabolic consequences of p300 gene deletion in tumor cells in vitro and in vivo.