J
Jacob G. Malone
Researcher at University of East Anglia
Publications - 59
Citations - 2552
Jacob G. Malone is an academic researcher from University of East Anglia. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 19, co-authored 43 publications receiving 2161 citations. Previous affiliations of Jacob G. Malone include University of Oxford & John Innes Centre.
Papers
More filters
Journal ArticleDOI
Mechanisms of Cyclic-di-GMP Signaling in Bacteria
Urs Jenal,Jacob G. Malone +1 more
TL;DR: This review examines several well-established model systems for c-di-GMP signaling, including Pseudomonas, Vibrio, Caulobacter, and Salmonella, and on their role in transmitting environmental stimuli into a range of different cellular functions.
Journal ArticleDOI
Genomic and genetic analyses of diversity and plant interactions of Pseudomonas fluorescens
Mark W. Silby,Ana Cerdeño-Tárraga,Georgios S. Vernikos,Stephen R. Giddens,Robert W. Jackson,Robert W. Jackson,Gail M. Preston,Xue-Xian Zhang,Christina D. Moon,Christina D. Moon,Stefanie M. Gehrig,Scott A. C. Godfrey,Scott A. C. Godfrey,Christopher Knight,Christopher Knight,Jacob G. Malone,Jacob G. Malone,Zena Robinson,Andrew J. Spiers,Andrew J. Spiers,Simon R. Harris,Gregory L. Challis,Alice M. Yaxley,David Harris,Kathy Seeger,Lee Murphy,Simon Rutter,Rob Squares,Michael A. Quail,Elizabeth Saunders,Konstantinos Mavromatis,Thomas Brettin,Stephen D. Bentley,Joanne Hothersall,Elton R. Stephens,Christopher M. Thomas,Julian Parkhill,Stuart B. Levy,Paul B. Rainey,Nicholas R. Thomson +39 more
TL;DR: A functional genomic in vivo expression technology (IVET) screen provided insight into genes used by P. fluorescens in its natural environment and an improved understanding of the ecological significance of diversity within this species.
Journal ArticleDOI
YfiBNR Mediates Cyclic di-GMP Dependent Small Colony Variant Formation and Persistence in Pseudomonas aeruginosa
Jacob G. Malone,Tina Jaeger,Christian Spangler,Daniel Ritz,Anne Spang,Cécile Arrieumerlou,Volkhard Kaever,Regine Landmann,Urs Jenal +8 more
TL;DR: YfiBNR is established as an important player in P. aeruginosa persistence, and implicates a central role for c-di-GMP, and by extension the SCV phenotype in chronic infections.
Journal ArticleDOI
The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain.
TL;DR: It is shown that WspR is a diguanylate cyclase (DGC), and that DGC activity is elevated in the WS genotype compared to that in the ancestral smooth (SM) genotype.
Journal ArticleDOI
Adaptive Divergence in Experimental Populations of Pseudomonas fluorescens. II. Role of the GGDEF Regulator WspR in Evolution and Development of the Wrinkly Spreader Phenotype
Patrick Goymer,Sophie G. Kahn,Jacob G. Malone,Stefanie M. Gehrig,Andrew J. Spiers,Paul B. Rainey,Paul B. Rainey +6 more
TL;DR: Ability to mimic this effect by overexpression of a liberated N-terminal domain shows that in WS, regulatory components upstream of WspR are overactive.