J
Jacopo Meldolesi
Researcher at Vita-Salute San Raffaele University
Publications - 169
Citations - 13780
Jacopo Meldolesi is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Exocytosis & Endoplasmic reticulum. The author has an hindex of 57, co-authored 162 publications receiving 12618 citations. Previous affiliations of Jacopo Meldolesi include Istituto Italiano di Tecnologia & Università telematica San Raffaele.
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Shedding microvesicles: artefacts no more
TL;DR: The small vesicles shed from the surface of many cells upon stimulation, considered for a long time to be artefacts, are now recognized as specific structures that are distinct from the exosomes released upon exocytosis of multivesicular bodies.
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Molecular and cellular physiology of intracellular calcium stores
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Ectosomes and exosomes: shedding the confusion between extracellular vesicles
TL;DR: The similarities and differences between these two classes of vesicle are reviewed, suggesting that, despite their considerable differences, the functions of ectosomes may be largely analogous to those of exosomes.
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CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity.
Paola Bezzi,Maria Domercq,Liliana Brambilla,Rossella Galli,Dominique Schols,Erik De Clercq,Angelo L. Vescovi,Giacinto Bagetta,George Kollias,Jacopo Meldolesi,Andrea Volterra +10 more
TL;DR: It is demonstrated that altered glial communication has direct neuropathological consequences and that agents interfering with CXCR4-dependent astrocyte–microglia signaling prevent neuronal apoptosis induced by the HIV-1 coat glycoprotein, gp120IIIB.
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Exosomes and Ectosomes in Intercellular Communication
TL;DR: Exosomes and ectosomes, two distinct types of extracellular vesicles generated by all types of cell, play key roles in intercellular communication and are useful in the development of innovative therapeutic approaches.