Luigi Iuliano

TL;DR: The results indicate that 8-epi PGF2alpha and IPF2alpha-I, two distinct F2-isoprostanes and markers of oxidative stress in vivo, are present in human atherosclerotic plaque.

TL;DR: Therapeutic interventions with antioxidants as antiplatelet agents are suggested to improve the pharmacological effect of classical antiplatelets drug such as aspirin.

TL;DR: Urinary IPF2α-I is a novel index of lipid peroxidation in vivo, which can be measured with precision and sensitivity and is highly correlated with urinary 8-iso-PGF2 Alpha, an isomer of the PGG/H synthase (cyclooxygenase or COX) enzyme product.

TL;DR: In the absence of enzymatic catalysis in a pathway usually termed "autoxidation", which has been known for almost a century and observed under various experimental conditions, the susceptibility of cholesterol to non-enzymatic oxidation has raised considerable interest in the function of oxysterols as biological effectors and potential biomarkers for the non-invasive study of oxidative stress in vivo as discussed by the authors.

TL;DR: All aspects examined in this critical review of the literature clearly suggest that further and more rigorous trials are needed together with new generations of pharmacological tools to a more effective antioxidant and anti-inflammatory therapy of cystic fibrosis patients.