Jacques Martal

TL;DR: The results indicate that the placentally produced anti-inflammatory cytokines can play a vital role in the survival to term of the fetal allograft, by counteracting deleterious inflammatory cytokines.

TL;DR: A systematic study of the expression of cytokines in the uterus, the peri-implantation embryo, and later on decidual and placental tissues throughout pregnancy suggests that the materno-foetal relationship is not simply maternal tolerance of a foreign tissue, but a series of intricate mutual cytokine interactions governing selective immune regulation and also control of the adhesion and vascularisation processes during this dialogue.

TL;DR: This paper briefly survey the history of concepts in reproductive immunology from antibody-mediated tolerance to the ‘fetal allograft’ to the current concept of an embryo ‘bathing in a sea of cytokines’, and shows the limits of the Th1/Th2 paradigm in pregnancy.

TL;DR: A striking correlation was observed for relative binding affinities towards ifnar1 and ifnar2 with the differential antiproliferative potency and this correlation was confirmed by systematically engineering IFNalpha2 mutants with very high differential antiprology potency.

TL;DR: Investigation of the expression of the two cyclooxygenases in sheep uterine tissues during the estrous cycle and early pregnancy demonstrated that cox-1 was localized in both epithelial and stromal cells, whereas coX-2 was localized solely in the luminal epithelium and to a lesser extent in the superficial glands.