J
Jae Hee Cheon
Researcher at Yonsei University
Publications - 455
Citations - 12131
Jae Hee Cheon is an academic researcher from Yonsei University. The author has contributed to research in topics: Inflammatory bowel disease & Medicine. The author has an hindex of 49, co-authored 400 publications receiving 9869 citations. Previous affiliations of Jae Hee Cheon include Sheba Medical Center & Severance Hospital.
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Journal ArticleDOI
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Jimmy Z. Liu,S van Sommeren,Hailiang Huang,Siew C. Ng,Rudi Alberts,Atsushi Takahashi,Stephan Ripke,James Lee,Luke Jostins,Tejas Shah,Shifteh Abedian,Jae Hee Cheon,Judy H. Cho,N E Dayani,Lude Franke,Yuta Fuyuno,Ailsa L. Hart,Ramesh C. Juyal,Garima Juyal,Won Ho Kim,Andrew P. Morris,Hossein Poustchi,William G. Newman,Vandana Midha,Timothy R. Orchard,H Vahedi,Ajit Sood,J Y Sung,Reza Malekzadeh,Westra H-J.,Keiko Yamazaki,Yang S-K.,Jeffrey C. Barrett,Behrooz Z. Alizadeh,Miles Parkes,T Bk,Mark J. Daly,Michiaki Kubo,Carl A. Anderson,Rinse K. Weersma +39 more
TL;DR: The first trans-ancestry association study of IBD is reported, with genome-wide or Immunochip genotype data from an extended cohort of 86,640 European individuals and immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent, implicate 38 loci in IBD risk for the first time.
Journal ArticleDOI
Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies.
Duk Hwan Kim,Jae Hee Cheon +1 more
TL;DR: Beyond conventional immunesuppressive therapy, the development of biological agents that target specific disease mechanisms has resulted in more frequent and deeper remission in IBD patients, with mucosal healing as a treatment goal of therapy.
Journal ArticleDOI
The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus
TL;DR: It is shown that metformin use in CRC patients with diabetes is associated with lower risk of CRC‐specific and overall mortality and after adjustment for clinically relevant factors, met formin use showed lowerrisk of overall mortality.
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Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations
Suk-Kyun Yang,Myunghee Hong,Wanting Zhao,Yusun Jung,Jiwon Baek,Naeimeh Tayebi,Kyung Mo Kim,Byong Duk Ye,Kyung-Jo Kim,Sang Hyoung Park,Inchul Lee,Eunju Lee,Won Ho Kim,Jae Hee Cheon,Young Ho Kim,Byung Ik Jang,Hyun Soo Kim,Jai Hyun Choi,Ja Seol Koo,Ji Hyun Lee,Sung Ae Jung,Yeoun Joo Lee,Joo Young Jang,Hyoung Doo Shin,Daehee Kang,Hee Shang Youn,Jianjun Liu,Kyuyoung Song +27 more
TL;DR: This study provides new biological insight to Crohn's disease and supports the complementary value of genetic studies in different populations.
Journal ArticleDOI
Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production
Jin Young Yang,Min-Soo Kim,Eugene Kim,Jae Hee Cheon,Yong-Soo Lee,Yeji Kim,Su-Hyun Lee,Sang Uk Seo,Seung-Ho Shin,Sun Shim Choi,Bumseok Kim,Sun Young Chang,Hyun-Jeong Ko,Jin-Woo Bae,Mi-Na Kweon +14 more
TL;DR: It is found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium (DSS)-induced colitis compared with untreated mice, implying that recognition of resident viruses by TLR3 and TLR7 is required for protective immunity during gut inflammation.